The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review

The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic... Am J Cardiovasc Drugs (2018) 18:93–102 https://doi.org/10.1007/s40256-017-0240-5 SYSTEMATIC REVIEW The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review 1 2 3 • • • Abdelrahman Elshafay Duy Hieu Truong Mohamed M. AboElnas 4 5 6,7 • • • Hossam Idrees Hatem G. Metwali Nguyen Lam Vuong 3 8 9,10 • • Omar Ahmed Saad Kenji Hirayama Nguyen Tien Huy Published online: 28 June 2017 Springer International Publishing AG 2017 Abstract and the WHO International Clinical Trials Registry Plat- Introduction The efficacy of endothelin receptor antago- form, through August 2016. We included randomized nists (ERAs) in the management of Eisenmenger syndrome clinical trials addressing the effect of ERAs on cardiac (ES) remains controversial. The aim of this study is to functions in patients with ES. The quality of studies was systemically review the safety and effects of ERAs in assessed using the Cochrane Collaboration tool. improving the quality of life and basic cardiac functions of Results We included two trials represented by four papers, these patients. of which three papers reported the efficacy of bosentan Methods Twelve databases were searched, including against placebo and one paper reported the results of a PubMed, Web of Science, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
D.O.I.
10.1007/s40256-017-0240-5
Publisher site
See Article on Publisher Site

Abstract

Am J Cardiovasc Drugs (2018) 18:93–102 https://doi.org/10.1007/s40256-017-0240-5 SYSTEMATIC REVIEW The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review 1 2 3 • • • Abdelrahman Elshafay Duy Hieu Truong Mohamed M. AboElnas 4 5 6,7 • • • Hossam Idrees Hatem G. Metwali Nguyen Lam Vuong 3 8 9,10 • • Omar Ahmed Saad Kenji Hirayama Nguyen Tien Huy Published online: 28 June 2017 Springer International Publishing AG 2017 Abstract and the WHO International Clinical Trials Registry Plat- Introduction The efficacy of endothelin receptor antago- form, through August 2016. We included randomized nists (ERAs) in the management of Eisenmenger syndrome clinical trials addressing the effect of ERAs on cardiac (ES) remains controversial. The aim of this study is to functions in patients with ES. The quality of studies was systemically review the safety and effects of ERAs in assessed using the Cochrane Collaboration tool. improving the quality of life and basic cardiac functions of Results We included two trials represented by four papers, these patients. of which three papers reported the efficacy of bosentan Methods Twelve databases were searched, including against placebo and one paper reported the results of a PubMed, Web of Science,

Journal

American Journal of Cardiovascular DrugsSpringer Journals

Published: Jun 28, 2017

References

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