Am J Cardiovasc Drugs (2018) 18:93–102 https://doi.org/10.1007/s40256-017-0240-5 SYSTEMATIC REVIEW The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review 1 2 3 • • • Abdelrahman Elshafay Duy Hieu Truong Mohamed M. AboElnas 4 5 6,7 • • • Hossam Idrees Hatem G. Metwali Nguyen Lam Vuong 3 8 9,10 • • Omar Ahmed Saad Kenji Hirayama Nguyen Tien Huy Published online: 28 June 2017 Springer International Publishing AG 2017 Abstract and the WHO International Clinical Trials Registry Plat- Introduction The efﬁcacy of endothelin receptor antago- form, through August 2016. We included randomized nists (ERAs) in the management of Eisenmenger syndrome clinical trials addressing the effect of ERAs on cardiac (ES) remains controversial. The aim of this study is to functions in patients with ES. The quality of studies was systemically review the safety and effects of ERAs in assessed using the Cochrane Collaboration tool. improving the quality of life and basic cardiac functions of Results We included two trials represented by four papers, these patients. of which three papers reported the efﬁcacy of bosentan Methods Twelve databases were searched, including against placebo and one paper reported the results of a PubMed, Web of Science,
American Journal of Cardiovascular Drugs – Springer Journals
Published: Jun 28, 2017
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