J Mater Sci: Mater Med (2017) 28:144 DOI 10.1007/s10856-017-5958-8 BIOCOMPATIBILITY STUDIES Original Research The effect of cationically-modiﬁed phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo 1 1 2 2 ● ● ● ● Jonathan M. Lawton Mariam Habib Bingkui Ma Roger A. Brooks 1 3 2 1 ● ● ● Serena M. Best Andrew L. Lewis Neil Rushton William Bonﬁeld Received: 30 January 2017 / Accepted: 3 August 2017 / Published online: 17 August 2017 © Springer Science+Business Media, LLC 2017 Abstract The effect of introducing cationic charge into biotolerant, stimulating the production of ﬁbrous tissue and phosphorylcholine (PC)-based polymers has been investi- areas of loosely associated matrix (LAM) around the gated in this study with a view to using these materials as implant. Their development, as formulated in this study, as coatings to improve bone formation and osseointegration at bone interfacing implant coatings is therefore not warranted. the bone-implant interface. PC-based polymers, which have been used in a variety of medical devices to improve bio- Graphical abstract compatibility, are associated with low protein adsorption resulting in reduced complement activation, inﬂammatory response and cell adhesion. However, in some applications, such as orthopaedics,
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Aug 17, 2017
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