Ir J Med Sci (2017) 186:621–629 DOI 10.1007/s11845-017-1580-5 ORIGINAL ARTICLE The effect of candesartan on pentraxin-3 plasma levels as marker of endothelial dysfunction in patients with essential arterial hypertension 1 2 1 1 2 3 • • • • • • V. Buda M. Andor C. Cristescu M. Voicu F. Cochera P. Tuduce 4 2 L. Petrescu M. C. Tomescu Received: 10 August 2016 / Accepted: 7 February 2017 / Published online: 21 February 2017 Royal Academy of Medicine in Ireland 2017 Abstract Methods A total of 365 patients were included in the Background In the last decades, the studies performed on study: 127 hypertensive patients were under treatment with the ﬁeld of endothelial dysfunction conﬁrmed the fact that candesartan, 134 patients were under treatment with other the starting point of this pathology is the inﬂammation. hypotensive medication (beta blockers, calcium channel Several inﬂammatory biomarkers had been discovered and blockers, and diuretics), both groups with controlled values studied, ones showing systemic inﬂammation, and others of blood pressure, and 104 were normotensive persons. being more speciﬁc biomarkers and showing the local Classical methods of assessing the endothelial function inﬂammation. Pentraxin-3 (PTX3) is a new inﬂammatory were correlated with these biochemical
Irish Journal of Medical Science (1971 -) – Springer Journals
Published: Feb 21, 2017
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