Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

The Effect of Acute Pulmonary Hypertension on Tricuspid Annular Height, Strain, and Curvature in Sheep

The Effect of Acute Pulmonary Hypertension on Tricuspid Annular Height, Strain, and Curvature in... The tricuspid annulus shows significant alterations in patients with functional tricuspid regurgitation–tricuspid valve dysfunction that is secondary to other diseases such as pulmonary hypertension. Early changes in annular shape and dynamics may provide an understanding of disease mechanisms and could predict disease progression. To gain a mechanistic insight into these early changes we perform a spatially-resolved analysis of the effect of acute pulmonary hypertension on the tricuspid annulus in sheep. To this end, we suture sonomicrometry crystals to the annulus of nine sheep and record their locations in the beating heart, before and after inducing acute pulmonary hypertension. Using least-squares cubic splines, we derive mathematical representations of the annulus to describe pulmonary hypertension-induced annular shape changes via strain, relative curvature, and relative annular height between the control group and the acute pulmonary hypertension group. Moreover, we determine hypertension-induced alterations to annular dynamics as within-group strains, relative curvature, and relative height throughout the cardiac cycle for each group. We confirm that the annulus in acute pulmonary hypertension dilates significantly, becomes more circular, and flattens. Our regional analysis reveals that annular dilation, circularization, and flattening are driven by highly localized changes in annular strains, curvature, and height. Additionally, we find that acute pulmonary hypertension alters annular dynamics, albeit minimally. This regionally-resolved analysis of acute hypertension-induced changes of annular shape and dynamics provides insight into early disease mechanisms, and may inspire future generations of annuloplasty devices and techniques that address spatial annular heterogeneities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Engineering and Technology Springer Journals

The Effect of Acute Pulmonary Hypertension on Tricuspid Annular Height, Strain, and Curvature in Sheep

Download PDF
12 pages
Read Article

Loading next page...
 
/lp/springer_journal/the-effect-of-acute-pulmonary-hypertension-on-tricuspid-annular-height-MwQlHdGnsu
Publisher
Springer Journals
Copyright
Copyright © 2018 by Biomedical Engineering Society
Subject
Engineering; Biomedical Engineering; Cardiology; Biomedicine, general
ISSN
1869-408X
eISSN
1869-4098
DOI
10.1007/s13239-018-0367-9
Publisher site
See Article on Publisher Site

Abstract

The tricuspid annulus shows significant alterations in patients with functional tricuspid regurgitation–tricuspid valve dysfunction that is secondary to other diseases such as pulmonary hypertension. Early changes in annular shape and dynamics may provide an understanding of disease mechanisms and could predict disease progression. To gain a mechanistic insight into these early changes we perform a spatially-resolved analysis of the effect of acute pulmonary hypertension on the tricuspid annulus in sheep. To this end, we suture sonomicrometry crystals to the annulus of nine sheep and record their locations in the beating heart, before and after inducing acute pulmonary hypertension. Using least-squares cubic splines, we derive mathematical representations of the annulus to describe pulmonary hypertension-induced annular shape changes via strain, relative curvature, and relative annular height between the control group and the acute pulmonary hypertension group. Moreover, we determine hypertension-induced alterations to annular dynamics as within-group strains, relative curvature, and relative height throughout the cardiac cycle for each group. We confirm that the annulus in acute pulmonary hypertension dilates significantly, becomes more circular, and flattens. Our regional analysis reveals that annular dilation, circularization, and flattening are driven by highly localized changes in annular strains, curvature, and height. Additionally, we find that acute pulmonary hypertension alters annular dynamics, albeit minimally. This regionally-resolved analysis of acute hypertension-induced changes of annular shape and dynamics provides insight into early disease mechanisms, and may inspire future generations of annuloplasty devices and techniques that address spatial annular heterogeneities.

Journal

Cardiovascular Engineering and Technology – Springer Journals

Published: Jun 1, 2018

References

  • On the biaxial mechanical response of porcine tricuspid valve leaflets
    Amini Khoiy, K; Amini, R
  • Surface strains of porcine tricuspid valve septal leaflets measured in ex vivo beating hearts
    Amini Khoiy, K; Biswas, D; Decker, TN; Asgarian, KT; Loth, F; Amini, R
  • Human cardiac function simulator for the optimal design of a novel annuloplasty ring with a sub-valvular element for correction of ischemic mitral regurgitation
    Baillargeon, B; Costa, I; Leach, JR; Lee, LC; Genet, M; Toutain, A
  • Annulus tension on the tricuspid valve: an in vitro study
    Basu, A; He, Z
  • Rigid, complete annuloplasty rings increase anterior mitral leaflet strains in the normal beating ovine heart
    Bothe, W; Kuhl, E; Kvitting, JPE; Rausch, MK; Göktepe, S; Swanson, JC
  • How do annuloplasty rings affect mitral annular strains in the normal beating ovine heart?
    Bothe, W; Rausch, MK; Kvitting, JPE; Echtner, DK; Walther, M; Ingels, NB
  • Computational systems mechanobiology of wound healing
    Buganza, Tepole A
  • Impact of pulmonary hypertension on tricuspid valve function
    Casa, LDCC; Dolensky, JR; Spinner, EM; Veledar, E; Lerakis, S; Yoganathan, AP
  • Review: functional tricuspid regurgitation: an underestimated issue
    Mauro, M; Bezante, GP; Baldassarre, A; Clemente, D; Cardinali, A; Acitelli, A
  • Secondary tricuspid regurgitation or dilatation: which should be the criteria for surgical repair?
    Dreyfus, GD; Corbi, PJ; Chan, KMJ; Bahrami, T
  • Functional tricuspid regurgitation: a need to revise our understanding
    Dreyfus, GD; Martin, RP; Chan, KMJ; Dulguerov, F; Alexandrescu, C
  • Three-dimensional geometry of the tricuspid annulus in healthy subjects and in patients with functional tricuspid regurgitation a real-time, 3-dimensional echocardiographic study
    Fukuda, S; Saracino, G; Matsumura, Y; Daimon, M; Tran, H; Greenberg, NL
  • Sonometric study of the normal tricuspid valve annulus in sheep
    Hiro, ME; Jouan, J; Pagel, MR; Lansac, E; Lim, KH; Lim, H-S
  • Anterior mitral leaflet curvature during the cardiac cycle in the normal ovine heart
    Kvitting, JPE; Bothe, W; Göktepe, S; Rausch, MK; Swanson, JC; Kuhl, E
  • Large animal model of functional tricuspid regurgitation in pacing induced end-stage heart failure
    Malinowski, M; Proudfoot, AG; Langholz, D; Eberhart, L; Brown, M; Schubert, H
  • The effect of acute mechanical left ventricular unloading on ovine tricuspid annular size and geometry
    Malinowski, M; Wilton, P; Khaghani, A; Brown, M; Langholz, D; Hooker, V
  • The effect of pulmonary hypertension on ovine tricuspid annular dynamics
    Malinowski, M; Wilton, P; Khaghani, A; Langholz, D; Hooker, V; Eberhart, L
  • Mechanism and implications of the tricuspid regurgitation: from the pathophysiology to the current and future therapeutic options
    Mangieri, A; Montalto, C; Pagnesi, M; Jabbour, RJ; Rodés-Cabau, J; Moat, N
  • Pathogenic structural heart changes in early tricuspid regurgitation
    Nemoto, N; Lesser, JR; Pedersen, WR; Sorajja, P; Spinner, E; Garberich, RF
  • In vitro system for measuring chordal force changes following mitral valve patch repair
    Ostli, B; Vester-Petersen, J; Askov, JB; Honge, JL; Levine, RA; Hagege, A
  • Tricuspid annulus: a three-dimensional deconstruction and reconstruction
    Owais, K; Taylor, CE; Jiang, L; Khabbaz, KR; Montealegre-Gallegos, M; Matyal, R
  • Suture dehiscence in the tricuspid annulus: an ex vivo analysis of tissue strength and composition
    Paul, DM; Naran, A; Pierce, EL; Bloodworth, CH; Bolling, SF; Yoganathan, AP
  • Mechanics of healthy and functionally diseased mitral valves: a critical review
    Rabbah, J-PM; Saikrishnan, N; Siefert, AW; Santhanakrishnan, A; Yoganathan, AP
  • Characterization of mitral valve annular dynamics in the beating heart
    Rausch, MK; Bothe, W; Kvitting, JPE; Swanson, JC; Ingels, NB; Miller, DC
  • Mitral valve annuloplasty: a quantitative clinical and mechanical comparison of different annuloplasty devices
    Rausch, MK; Bothe, W; Kvitting, JPE; Swanson, JC; Miller, DC; Kuhl, E
  • Engineering analysis of tricuspid annular dynamics in the beating ovine heart
    Rausch, MK; Malinowski, M; Wilton, P; Khaghani, A; Timek, TA
  • Mechanics of the mitral annulus in chronic ischemic cardiomyopathy
    Rausch, MK; Tibayan, FA; Ingels, NB; Miller, DC; Kuhl, E
  • Effect of annular shape on leaflet curvature in reducing mitral leaflet stress
    Salgo, IS; Gorman, JH; Gorman, RC; Jackson, BM; Bowen, FW; Plappert, T
  • Quantitative evaluation of annuloplasty on mitral valve chordae tendineae forces to supplement surgical planning model development
    Siefert, AW; Rabbah, JPM; Pierce, EL; Kunzelman, KS; Yoganathan, AP
  • Morphology of the human tricuspid valve
    Silver, MD; Lam, JHC; Ranganathan, N; Wigle, ED
  • The effects of a three-dimensional, saddle-shaped annulus on anterior and posterior leaflet stretch and regurgitation of the tricuspid valve
    Spinner, EM; Buice, D; Yap, CH; Yoganathan, AP
  • Correlates of tricuspid regurgitation as determined by 3d echocardiography: pulmonary arterial pressure, ventricle geometry, annular dilatation and papillary muscle displacement
    Spinner, EM; Lerakis, S; Higginson, J; Pernetz, M; Howell, S; Veledar, E
  • Heterogeneity of mitral leaflet matrix composition and turnover correlates with regional leaflet strain
    Stephens, EH; Connell, PS; Fahrenholtz, MM; Timek, TA; Daughters, GT; Kuo, JJ
  • Cellular and extracellular matrix basis for heterogeneity in mitral annular contraction
    Stephens, EH; Fahrenholtz, MM; Connell, PS; Timek, TA; Daughters, GT; Kuo, JJ
  • Geometric changes of tricuspid valve tenting in tricuspid regurgitation secondary to pulmonary hypertension quantified by novel system with transthoracic real-time 3-dimensional echocardiography
    Sukmawan, R; Watanabe, N; Ogasawara, Y; Yamaura, Y; Yamamoto, K; Wada, N
  • The growing clinical importance of secondary tricuspid regurgitation
    Taramasso, M; Vanermen, H; Maisano, F; Guidotti, A; Canna, G; Alfieri, O
  • The tricuspid valve annulus: study of size and motion in normal subjects and in patients with tricuspid regurgitation
    Tei, C; Pilgrim, JP; Shah, PM; Ormiston, JA; Wong, M
  • Geometric determinants of functional tricuspid regurgitation: insights from 3-dimensional echocardiography
    Ton-Nu, TT; Levine, RA; Handschumacher, MD; Dorer, DJ; Yosefy, C; Fan, D
  • Tricuspid valve remodelling in functional tricuspid regurgitation: multidetector row computed tomography insights
    Rosendael, PJ; Joyce, E; Katsanos, S; Debonnaire, P; Kamperidis, V; Kley, F

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial