Purpose To evaluate the effect of 12-month DHEA supplementation on menstrual pattern and ovarian reserve markers in women with premature ovarian insufficiency (POI) Methods This is a prospective observational study. Women with POI were given DHEA supplements (25 mg three times daily) for 12 months. Sonographic assessment for ovarian volume and antral follicle count (AFC) and serum measurement for anti- Mullerian hormone (AMH), follicle stimulating hormone (FSH), estradiol, testosterone, liver function, and hemoglobin level were performed at baseline and monthly for 13 months after the supplementation. Menstrual pattern, ovarian reserve markers, and side-effects were recorded. Results Between August 2011 and July 2014, 38 women with POI were recruited and 31 completed the study. The median age of women was 36 years, and the median baseline FSH and AMH concentrations were 82.2 IU/L and 0.01 ng/ml, respectively. No women had resumption of regular menstruation after DHEA supplementation. AMH, FSH, and AFC did not change signifi- cantly. No serious side effects were reported. Conclusions Our results do not support any significant improvement in ovarian function by 12-month DHEA supplementation in women with POI. . . . . Keywords Dehydroepiandrosterone Premature ovarian insufficiency Anti-Mullerian hormone Follicle-stimulating hormone Antral follicle count Introduction diagnosed
Journal of Assisted Reproduction and Genetics – Springer Journals
Published: Mar 9, 2018
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