Short Communications Incorporating Mouse Genome Mammalian Genome 9, 588–589 (1998). © Springer-Verlag New York Inc. 1998 The dominant mouse mutations Fused toes (Ft) and oligosyndactylism (Os) are not allelic Ralf Lesche, Ulrich Ru ¨ ther Institut fu ¨ r Molekularbiologie, OE5250 Medizinische Hochschule Hannover, 30623 Hannover, Germany Received: 13 January 1998 / Accepted: 12 March 1998 The outgrowth of the vertebrate limb is one of the classical model ment (Gru ¨ neberg 1956) which suggests a genomic deletion to be systems to study developmental processes (for a review see Tickle the molecular cause. The comparison of both mutant phenotypes 1995). Morphogenetic mouse mutants in which limb development let us hypothesize that Ft and Os might be allelic. Genes deleted or is affected have proven useful to analyze the molecular mecha- mutated by both mutations would be good candidates to function nisms underlying this process (for a review, see Cohn and Tickle in limb development. 1996). Fused toes (Ft) is a dominant mouse mutation characterized To address the question of allelism of Ft and Os, we have by partial syndactyly of fore limbs and thymic hyperplasia. Ho- crossed Ft/+ and Os/+ mice. Fifty-nine offspring from a cross of mozygous Ft
Mammalian Genome – Springer Journals
Published: Jul 1, 1998
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