Can J Anesth/J Can Anesth https://doi.org/10.1007/s12630-018-1153-8 IMAGES IN ANESTHESIA Kim E. Turner, BScPhm, MSc, MD, FRCPC Received: 10 May 2018 / Accepted: 10 May 2018 Canadian Anesthesiologists’ Society 2018 There was a worldwide quest during the early part of the 20th century to discover an anesthetic agent that could augment or replace the commonly used agents of the time – namely ether, choloroform, and nitrous oxide. Among those pursuing this line of research was Dr. Velyien E. Henderson, Professor of Pharmacology at the University of Toronto, working with Dr. W. Easson Brown, an assistant in the University’s Department of Pharmacology, who was an anesthesiologist at the Toronto General Hospital. Their initial experimentation with propylene had shown promise when the gas was freshly prepared. After storage under pressure in steel tanks, however, its administration induced nausea and cardiac irregularities. Dr. George H. Lucas, a new chemist working with Dr. Henderson, wondered if the toxic contaminant might be cyclopropane, formed when propylene is prepared. Indeed, his analysis of the stored propylene revealed that its isomer, cyclopropane, was also present in the stored tank. In 1928, Dr. Lucas subsequently isolated and puriﬁed a sample of cyclopropane, believing it to be a toxic
Canadian Journal of Anesthesia/Journal canadien d'anesthésie – Springer Journals
Published: May 31, 2018
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