Curr Stem Cell Rep (2017) 3:218–224 DOI 10.1007/s40778-017-0092-6 CELL:CELL INTERACTIONS IN STEM CELL MAINTENANCE (D BONNET, SECTION EDITOR) The Distinct Role of Extracellular Vesicles Derived from Normal and Cancer Stem Cells 1 1 1 2 Cristina Grange & Marta Tapparo & Sharad Kholia & Benedetta Bussolati & Giovanni Camussi Published online: 13 July 2017 Springer International Publishing AG 2017 . . . Abstract Keywords Exosomes Microvesicles Stemness Purpose of Review Extracellular vesicles (EVs) are a power- Regeneration Tumor progression and metastasis ful tool for intercellular messages. EVs display many charac- teristics of the cell of origin and may mimic the biological activities of cells. In this review, we summarize the updated Introduction knowledge regarding the biological role of EVs released by both types of healthy somatic stem cells and cancer stem cells In the last decade, many studies have tried to characterize and (CSCs). Adult somatic stem cells influence the regeneration elucidate a new mechanism of cell-to-cell communication ca- and healing of damaged tissues in various models of tissue pable of influencing the phenotype of target cells through the injury; on the other hand, CSCs retain some characteristics of release of vesicles . Extracellular vesicles (EVs) are healthy stem
Current Stem Cell Reports – Springer Journals
Published: Jul 13, 2017
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