Short Communications e//o///e Mammalian Genome 8, 581-582 (1997). 9 Springer-Verlag New York Inc. 1997 The costimulatory genes Cd80 and Cd86 are linked on mouse Chromosome 16 and human Chromosome 3 Roger H. Reeves, 1 David Patch, 1 Arlene H. Sharpe, 2 Frank Borriello, 2 Gordon J. Freeman, 3 Susanne Edelhoff, 4 Christine Disteche 4 ~Department of Physiology, 202 Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA 2Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 3Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA 4Department of Pathology, University of Washington, Seattle, Washington 98155, USA Received: 5 December 1996 / Accepted: 23 March 1997 B7-1 and B7-2 are structurally similar members of the immuno- (499 backcross progeny/47 recombinant progeny = 10.61; Reeves globulin superfamily expressed on a variety of hematopoietic cell et al. 1990). Locus order and calculated distance from this analysis types. They provide a costimulatory signal to T cells by interacting were Smst-5.9cM-Cd86/D16Mit11-O.7-D16Mit59-O.2-Cd80- with the T cell surface molecules, CD28 and CTLA4. The amino 2.7-Gap43. acid identity between mouse and human and between B7-1 and Because four of these markers were separated
Mammalian Genome – Springer Journals
Published: Apr 1, 2009
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