J. Membrane Biol. 210, 75 (2006) DOI: 10.1007/s00232-005-0846-4 Thematic Issue A.E. Hill, Guest Editor Foreword A.E. Hill The Physiological Laboratory, University of Cambridge, Downing St., Cambridge CB2 3EG, UK Received: 16 January 2006 The control of water movement in tissues and cells is techniques developed in their laboratory, an area of great current interest. Alongside the whilst Burghardt et al. provide an overview of pan- standard view, that ﬂuids move across cell mem- creatic ﬂuid production which demonstrates the branes by osmosis, and its natural extension to epi- complexity of this system. On the other hand, Hill thelial ﬂuid transport and water movement in plants and Shachar-Hill propose a model involving para- driven by osmotic gradients, others have co-existed, cellular transport controlled by AQPs which gains involving transport by the paracellular system. The support from the study of Murakami et al. on the discovery of aquaporins (AQPs) gave considerable salivary gland, involving rat strains deﬁcient in impetus to the subject but the ﬁeld is becoming more AQPs. The paracellular route is the basis of a new complicated, not only by the variety and distribution model by Fischbarg et al. for ﬂuid transport in the of AQPs, but by the fact that their removal by genetic corneal endothelium in which electro-kinetic eﬀects manipulation has only a slight eﬀect on ﬂuid move- are clearly involved. In plants, which express a ment in many cases. plethora of AQPs, MacRobbie reviews the control of In this Issue there is a spectrum of views about water ﬂow in stomatal guard cells and presents evi- the transport of water and its possible relation to dence that AQPs may be involved in turgor control. aquaporins, much of it involving epithelia. From the Finally, Sugiya and Matsuki show that AQP is in- traditional viewpoint, Levin and Verkman review the volved in the control of vesicle swelling and volume considerable data on the epithelial systems of the eye, control in salivary cells. much of which has come from mouse models and The ﬁeld is at an interesting stage, possibly an unstable one, in which new approaches and para- digms are likely to emerge in the near future. The Key words: Fluid transport — Epithelia — AQP mechanisms involved in the control of ﬂuid move- control — Paracellular ﬂow — Volume control — ments are so important that their elucidation may Water ﬂow transform many areas of cell physiology. Correspondence to: A.E. Hill; email: email@example.com
The Journal of Membrane Biology – Springer Journals
Published: Jul 25, 2006
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