The Control of Fluid Transport in Tissues and Cells

The Control of Fluid Transport in Tissues and Cells J. Membrane Biol. 210, 75 (2006) DOI: 10.1007/s00232-005-0846-4 Thematic Issue A.E. Hill, Guest Editor Foreword A.E. Hill The Physiological Laboratory, University of Cambridge, Downing St., Cambridge CB2 3EG, UK Received: 16 January 2006 The control of water movement in tissues and cells is techniques developed in their laboratory, an area of great current interest. Alongside the whilst Burghardt et al. provide an overview of pan- standard view, that fluids move across cell mem- creatic fluid production which demonstrates the branes by osmosis, and its natural extension to epi- complexity of this system. On the other hand, Hill thelial fluid transport and water movement in plants and Shachar-Hill propose a model involving para- driven by osmotic gradients, others have co-existed, cellular transport controlled by AQPs which gains involving transport by the paracellular system. The support from the study of Murakami et al. on the discovery of aquaporins (AQPs) gave considerable salivary gland, involving rat strains deficient in impetus to the subject but the field is becoming more AQPs. The paracellular route is the basis of a new complicated, not only by the variety and distribution model by Fischbarg et al. for fluid transport in the of AQPs, but by the fact that their removal by genetic corneal endothelium in which electro-kinetic effects manipulation has only a slight effect on fluid move- are clearly involved. In plants, which express a ment in many cases. plethora of AQPs, MacRobbie reviews the control of In this Issue there is a spectrum of views about water flow in stomatal guard cells and presents evi- the transport of water and its possible relation to dence that AQPs may be involved in turgor control. aquaporins, much of it involving epithelia. From the Finally, Sugiya and Matsuki show that AQP is in- traditional viewpoint, Levin and Verkman review the volved in the control of vesicle swelling and volume considerable data on the epithelial systems of the eye, control in salivary cells. much of which has come from mouse models and The field is at an interesting stage, possibly an unstable one, in which new approaches and para- digms are likely to emerge in the near future. The Key words: Fluid transport — Epithelia — AQP mechanisms involved in the control of fluid move- control — Paracellular flow — Volume control — ments are so important that their elucidation may Water flow transform many areas of cell physiology. Correspondence to: A.E. Hill; email: aeh1@hermes.cam.ac.uk http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

The Control of Fluid Transport in Tissues and Cells

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Publisher
Springer-Verlag
Copyright
Copyright © 2006 by Springer Science+Business Media, Inc.
Subject
Life Sciences; Human Physiology; Biochemistry, general
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-005-0846-4
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 210, 75 (2006) DOI: 10.1007/s00232-005-0846-4 Thematic Issue A.E. Hill, Guest Editor Foreword A.E. Hill The Physiological Laboratory, University of Cambridge, Downing St., Cambridge CB2 3EG, UK Received: 16 January 2006 The control of water movement in tissues and cells is techniques developed in their laboratory, an area of great current interest. Alongside the whilst Burghardt et al. provide an overview of pan- standard view, that fluids move across cell mem- creatic fluid production which demonstrates the branes by osmosis, and its natural extension to epi- complexity of this system. On the other hand, Hill thelial fluid transport and water movement in plants and Shachar-Hill propose a model involving para- driven by osmotic gradients, others have co-existed, cellular transport controlled by AQPs which gains involving transport by the paracellular system. The support from the study of Murakami et al. on the discovery of aquaporins (AQPs) gave considerable salivary gland, involving rat strains deficient in impetus to the subject but the field is becoming more AQPs. The paracellular route is the basis of a new complicated, not only by the variety and distribution model by Fischbarg et al. for fluid transport in the of AQPs, but by the fact that their removal by genetic corneal endothelium in which electro-kinetic effects manipulation has only a slight effect on fluid move- are clearly involved. In plants, which express a ment in many cases. plethora of AQPs, MacRobbie reviews the control of In this Issue there is a spectrum of views about water flow in stomatal guard cells and presents evi- the transport of water and its possible relation to dence that AQPs may be involved in turgor control. aquaporins, much of it involving epithelia. From the Finally, Sugiya and Matsuki show that AQP is in- traditional viewpoint, Levin and Verkman review the volved in the control of vesicle swelling and volume considerable data on the epithelial systems of the eye, control in salivary cells. much of which has come from mouse models and The field is at an interesting stage, possibly an unstable one, in which new approaches and para- digms are likely to emerge in the near future. The Key words: Fluid transport — Epithelia — AQP mechanisms involved in the control of fluid move- control — Paracellular flow — Volume control — ments are so important that their elucidation may Water flow transform many areas of cell physiology. Correspondence to: A.E. Hill; email: aeh1@hermes.cam.ac.uk

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jul 25, 2006

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