Purpose of Review Injured skin in the mammalian fetus can blasts are refractory to the environmental stimuli necessary for heal regeneratively due to the ability of fetal fibroblasts to myofibroblast differentiation in adult wound healing includ- effectively reorganize the extracellular matrix (ECM). This ing mechanical stress. Summary Understanding the biomechanical mechanisms that process occurs without fetal fibroblasts differentiating into highly contractile myofibroblasts which cause scarring and regulate the contractile phenotype of fetal fibroblasts may un- lock new avenues for anti-scarring therapies that target fibrosis in adult wounds. Here, we provide a brief review of fetal wound healing and the evidence supporting a unique myofibroblast differentiation of adult fibroblasts. contractile phenotype in fetal fibroblasts. Furthermore, we . . . . discuss the biomechanical role of the ECM in driving Keywords Wound healing Fetal Scarless Regeneration myofibroblast differentiation in wound healing and the impli- Myofibroblast Contractility cations for new clinical modalities based on the biophysical properties of fetal fibroblasts. Introduction Injuries to tissues resulting from traumas, surgeries, and dis- This article is part of the Topical Collection on Wound Healing and Tissue Repair eases are a leading global health concern. In the USA alone, treatments for dermal wounds cost tens of
Current Pathobiology Reports – Springer Journals
Published: Jul 28, 2017
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