The construction of defective interfering rubella virus particles

The construction of defective interfering rubella virus particles Two defective viral vectors containing nucleic acid sequences from rubella virus strains RJ and RS linked to the reporter gene luciferase have been constructed. The vector RNAs are shown to replicate and interfere with wild-type virus in co-infected cells. The interference is associated with a polymorphic nucleotide at nt34 in the 5′ stem-loop. The use of these constructs as expression vectors is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The construction of defective interfering rubella virus particles

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Publisher
Springer-Verlag
Copyright
Copyright © 2000 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050051
Publisher site
See Article on Publisher Site

Abstract

Two defective viral vectors containing nucleic acid sequences from rubella virus strains RJ and RS linked to the reporter gene luciferase have been constructed. The vector RNAs are shown to replicate and interfere with wild-type virus in co-infected cells. The interference is associated with a polymorphic nucleotide at nt34 in the 5′ stem-loop. The use of these constructs as expression vectors is discussed.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2000

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