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Wang Rong-geng (2008)
Protection of Amino Group in the 2-Aminomethylphenylacetic Acid,the Intermediate of CeforanideFine and Specialty Chemicals
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The protection and application of amino in organic synthesis
2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in 2-aminomethylphenylacetic acid by BOC (Di-tert butyl dicarbonate) or acetacetic ester, and compared the deprotection condition. The yield was higher when BOC was used as protecting agent, but when it was deprotected, it was more difficult than when acetacetic ester was used as protecting agent.
Research on Chemical Intermediates – Springer Journals
Published: Mar 12, 2013
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