The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid

The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid 2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in 2-aminomethylphenylacetic acid by BOC (Di-tert butyl dicarbonate) or acetacetic ester, and compared the deprotection condition. The yield was higher when BOC was used as protecting agent, but when it was deprotected, it was more difficult than when acetacetic ester was used as protecting agent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1069-4
Publisher site
See Article on Publisher Site

Abstract

2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in 2-aminomethylphenylacetic acid by BOC (Di-tert butyl dicarbonate) or acetacetic ester, and compared the deprotection condition. The yield was higher when BOC was used as protecting agent, but when it was deprotected, it was more difficult than when acetacetic ester was used as protecting agent.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Mar 12, 2013

References

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