The Comparative Study of the Frequency of P53 and Ki67 Markers in Ovarian Epithelial Tumors and Their Relationship with Survival in Patients Presenting to Shahid Sadoughi Hospital of Yazd in 2013–2017

The Comparative Study of the Frequency of P53 and Ki67 Markers in Ovarian Epithelial Tumors and... Introduction Ovarian cancer is the fifth cause of cancer death among women. P53 gene and Ki67 can play a significant role in the progression of tumors. This study was conducted to review the frequency of P53 and Ki67 markers in different types of ovarian epithelial tumors and their relationship with the prognosis of the disease. Materials and Methods This descriptive analytical study was done on all paraffin-embedded blocks of patients with ovarian surface epithelial tumors (malignant, benign, and borderline) referred to pathology ward of Shahid Sadoughi educational General Hospital from 2013 to 2017 by using the census method. Ki67 and P53 immunohistochemical tests were then performed on all the samples. Data such as (age, pathology report, survival status, affected side, size of tumor) were extracted from the hospital folders. Data were analyzed in SPSS version 22. P \ 0.05 was set as the level of statistical significance. Results A total of 86 cases, including 40 serous and mucinous carcinomas, 36 serous and mucinous cystadenomas, and ten serous and mucinous borderline tumors, were examined. The mean age of the patients was 44.29 ± 16.91 years, and their age range was 15–79. A significant relationship was found between the type of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

The Comparative Study of the Frequency of P53 and Ki67 Markers in Ovarian Epithelial Tumors and Their Relationship with Survival in Patients Presenting to Shahid Sadoughi Hospital of Yazd in 2013–2017

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-018-0202-0
Publisher site
See Article on Publisher Site

Abstract

Introduction Ovarian cancer is the fifth cause of cancer death among women. P53 gene and Ki67 can play a significant role in the progression of tumors. This study was conducted to review the frequency of P53 and Ki67 markers in different types of ovarian epithelial tumors and their relationship with the prognosis of the disease. Materials and Methods This descriptive analytical study was done on all paraffin-embedded blocks of patients with ovarian surface epithelial tumors (malignant, benign, and borderline) referred to pathology ward of Shahid Sadoughi educational General Hospital from 2013 to 2017 by using the census method. Ki67 and P53 immunohistochemical tests were then performed on all the samples. Data such as (age, pathology report, survival status, affected side, size of tumor) were extracted from the hospital folders. Data were analyzed in SPSS version 22. P \ 0.05 was set as the level of statistical significance. Results A total of 86 cases, including 40 serous and mucinous carcinomas, 36 serous and mucinous cystadenomas, and ten serous and mucinous borderline tumors, were examined. The mean age of the patients was 44.29 ± 16.91 years, and their age range was 15–79. A significant relationship was found between the type of

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Apr 24, 2018

References

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