The Combined Effect of Amniotic Membrane and Moringa oleifera Leaves Derived Gel for Wound and Burn Healing in Rat Model

The Combined Effect of Amniotic Membrane and Moringa oleifera Leaves Derived Gel for Wound and... A burn is a devastating phenomenon, especially in the developing countries. A bulk amount of medical resources is required to fulfill the demand of burned patients. So, it is very important to find another alternative for the treatment of burned patients. Recently, human amniotic membrane (AM) and Moringa oleifera (MO) are being used separately to treat wounds and burn. In this study, we tried to use a mix of AM and MO formulated to a gel with sodium carboxymethylcellulose (CMC-Na), propylparaben, glycerin, distilled water, and triethanolamine and applied on the burned skin of Wistar rats. Second-degree burns were created using pieces of aluminum (2.5-cm diameter). Skin irritation study, physiological properties, the percentage of wound contraction, and epithelialization period were measured for all groups. AM+MO-treated group had maximum average body weight, food intake, and water intake. At day 24, AM+MO group showed a greater response (p < 0.00003667) than other groups. For complete epithelialization, AM+MO required only 19.6 days while AM, MO, and control group needed 23.2, 28.2, and 31.4 days, respectively. These results suggested that the combined composition of AM+MO may be used as a good therapeutic agent to treat burn and wound. Lay Summary Since burn injury is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Regenerative Engineering and Translational Medicine Springer Journals

The Combined Effect of Amniotic Membrane and Moringa oleifera Leaves Derived Gel for Wound and Burn Healing in Rat Model

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by The Regenerative Engineering Society
Subject
Materials Science; Biomaterials; Regenerative Medicine/Tissue Engineering; Biomedical Engineering
ISSN
2364-4133
eISSN
2364-4141
D.O.I.
10.1007/s40883-018-0060-4
Publisher site
See Article on Publisher Site

Abstract

A burn is a devastating phenomenon, especially in the developing countries. A bulk amount of medical resources is required to fulfill the demand of burned patients. So, it is very important to find another alternative for the treatment of burned patients. Recently, human amniotic membrane (AM) and Moringa oleifera (MO) are being used separately to treat wounds and burn. In this study, we tried to use a mix of AM and MO formulated to a gel with sodium carboxymethylcellulose (CMC-Na), propylparaben, glycerin, distilled water, and triethanolamine and applied on the burned skin of Wistar rats. Second-degree burns were created using pieces of aluminum (2.5-cm diameter). Skin irritation study, physiological properties, the percentage of wound contraction, and epithelialization period were measured for all groups. AM+MO-treated group had maximum average body weight, food intake, and water intake. At day 24, AM+MO group showed a greater response (p < 0.00003667) than other groups. For complete epithelialization, AM+MO required only 19.6 days while AM, MO, and control group needed 23.2, 28.2, and 31.4 days, respectively. These results suggested that the combined composition of AM+MO may be used as a good therapeutic agent to treat burn and wound. Lay Summary Since burn injury is

Journal

Regenerative Engineering and Translational MedicineSpringer Journals

Published: Jun 4, 2018

References

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