ORIGINAL PAPER
The clinical characteristics and prognosis of acute zonal
occult outer retinopathy
Shancheng Si
.
Wei Song
.
Yifan Song
.
Yuntao Hu
Received: 17 January 2017 / Accepted: 25 May 2017 / Published online: 1 June 2017
Ó Springer Science+Business Media Dordrecht 2017
Abstract
Purpose This prospective observational case series
study aimed to observe the clinical characteristics of
acute zonal occult outer retinopathy (AZOOR) and its
prognosis in Chinese Han patients.
Methods Six eyes of 5 female patients diagnosed with
AZOOR were followed up for 4 months to observe the
natural disease course. All enrolled subjects underwent a
series of ocular examinations at the onset and each return
visit, including best corrected visual acuity (BCVA), split
lamp microscopy, fundus photography, optical coherence
tomography (OCT), perimetry, multifocal electroretino-
gram and fundus fluorescein angiography.
Results Over the follow-up, all enrolled patients
recovered on BCVA, perimetry and OCT in different
degrees. Among them, one patient recovered completely
since the ocular examination results returned to normal.
Conclusion AZOOR is a rare ocular disorder in
Chinese population. Our results demonstrated that
visual functions of enrolled patients significantly
improved spontaneously, indicating that Chinese
female Han patients with AZOOR have good visual
outcomes during the follow-up period without any
specific managements.
Keywords Acute zonal occult outer retinopathy Á
Optical coherence tomography Á Goldmann
perimetry Á Fundus fluorescein angiography Á
Multifocal electroretinogram
Introduction
Acute zonal occult outer retinopathy (AZOOR), first
reported in 1993 by Gass [1], is a rare unilateral or
bilateral ocular disorder, characterized by acute zonal
loss of outer retinal function [2, 3]. The prevalence of
this rare ocular disorder is not available right now by
searching the studies. The symptoms of AZOOR consist
of acute scotoma in visual field (100% of all patients)
and photopsia (about 60% of all patients) [4, 5]. With
Shancheng Si and Wei Song have contributed equally to the
present work.
S. Si Á Y. Hu (&)
Department of Ophthalmology, Beijing Tsinghua
Changgung Hospital, Tsinghua University, No. 168
Litang Road, Changping District, Beijing 102218, China
e-mail: ythu203@163.com
S. Si
e-mail: sishancheng@126.com
W. Song
Department of Ophthalmology, Jiaxing Traditional
Chinese Medicine Hospital Affiliated to Zhejiang Chinese
Medical University, Zhongshan East Road 1501,
Nanhu District, Jiaxing City 314000, Zhejiang Province,
China
e-mail: wsongzj@163.com
Y. Song Á Y. Hu
Department of Ophthalmology, Peking University Third
Hospital, 49 Huayuan North Road, Haidian District,
Beijing 100191, China
123
Int Ophthalmol (2018) 38:1177–1185
https://doi.org/10.1007/s10792-017-0580-9
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