The characterization of a mouse mutant that displays abnormal mammary gland development

The characterization of a mouse mutant that displays abnormal mammary gland development Mammalian Genome 11, 234–237 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 The characterization of a mouse mutant that displays abnormal mammary gland development Beatrice A. Howard, Barry A. Gusterson Institute of Cancer Research, The Breakthrough Toby Robins Breast Cancer Research Centre, Section of Cell Biology and Experimental Pathology, 237 Fulham Road, London SW3 6JB, UK Received: 27 January 1999 / Accepted: 21 October 1999 Deficiencies and supernumerary mammary glands in inbred strains of mice have been reported and were postulated to have a genetic basis (Gardner and Strong 1935; Little and McDonald 1965). Here we describe a naturally occurring mouse mutation named scaramanga that displays abnormal embryonic and postnatal mam- mary gland development found in the A/J strain of mice. We have performed a genetic analysis of this mutation and have determined that a single autosomal recessive locus appears to be responsible for this trait. The question of how body patterns are formed is a central theme of developmental biology. Little is known about the mo- lecular events that specify the site of organ development within a larger, morphologically indistinguishable region. In mice, five pairs of mammary glands are arranged in an ordered array along the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The characterization of a mouse mutant that displays abnormal mammary gland development

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Publisher
Springer-Verlag
Copyright
Copyright © 2000 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010043
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 11, 234–237 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 The characterization of a mouse mutant that displays abnormal mammary gland development Beatrice A. Howard, Barry A. Gusterson Institute of Cancer Research, The Breakthrough Toby Robins Breast Cancer Research Centre, Section of Cell Biology and Experimental Pathology, 237 Fulham Road, London SW3 6JB, UK Received: 27 January 1999 / Accepted: 21 October 1999 Deficiencies and supernumerary mammary glands in inbred strains of mice have been reported and were postulated to have a genetic basis (Gardner and Strong 1935; Little and McDonald 1965). Here we describe a naturally occurring mouse mutation named scaramanga that displays abnormal embryonic and postnatal mam- mary gland development found in the A/J strain of mice. We have performed a genetic analysis of this mutation and have determined that a single autosomal recessive locus appears to be responsible for this trait. The question of how body patterns are formed is a central theme of developmental biology. Little is known about the mo- lecular events that specify the site of organ development within a larger, morphologically indistinguishable region. In mice, five pairs of mammary glands are arranged in an ordered array along the

Journal

Mammalian GenomeSpringer Journals

Published: Feb 26, 2014

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