Mammalian Genome 11, 234–237 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 The characterization of a mouse mutant that displays abnormal mammary gland development Beatrice A. Howard, Barry A. Gusterson Institute of Cancer Research, The Breakthrough Toby Robins Breast Cancer Research Centre, Section of Cell Biology and Experimental Pathology, 237 Fulham Road, London SW3 6JB, UK Received: 27 January 1999 / Accepted: 21 October 1999 Deficiencies and supernumerary mammary glands in inbred strains of mice have been reported and were postulated to have a genetic basis (Gardner and Strong 1935; Little and McDonald 1965). Here we describe a naturally occurring mouse mutation named scaramanga that displays abnormal embryonic and postnatal mam- mary gland development found in the A/J strain of mice. We have performed a genetic analysis of this mutation and have determined that a single autosomal recessive locus appears to be responsible for this trait. The question of how body patterns are formed is a central theme of developmental biology. Little is known about the mo- lecular events that specify the site of organ development within a larger, morphologically indistinguishable region. In mice, five pairs of mammary glands are arranged in an ordered array along the
Mammalian Genome – Springer Journals
Published: Feb 26, 2014
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera