J Membrane Biol (2014) 247:1–8 DOI 10.1007/s00232-013-9604-1 O R I G IN AL ARTI CL ES The Cell Membrane is the Main Target of Resveratrol as Shown by Interdisciplinary Biomolecular/Cellular and Biophysical Approaches • • • G. L. Milardi A. Stringaro M. Colone A. Bonincontro G. Risuleo Received: 18 April 2013 / Accepted: 30 September 2013 / Published online: 29 October 2013 Springer Science+Business Media New York 2013 Abstract One of the research lines developed in our Keywords Resveratrol Cytotoxicity Cell laboratory is focused on the study of the bioactivity of membrane Cytoﬂuorometry Electrorotation natural substances. Resveratrol (RV) is a polyphenol non- ﬂavonoid compound present in a number of plant species but mainly in the berries of the red grape Vitis vinifera. The Introduction powerful antioxidant action of this molecule is well doc- Resveratrol (RV) is a polyphenol nonﬂavonoid compound umented. In this work we evaluated the effects of this substance by adopting diverse experimental strategies. In belonging to the family of natural phytoalexins which are produced by plants to combat the attack of pathogens particular, we studied the effects on cell vitality and cycle by MTT and cytoﬂuorimetric assays. In addition, we and/or stress.
The Journal of Membrane Biology – Springer Journals
Published: Oct 29, 2013
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