J. Membrane Biol. 176, 187–206 (2000) The Journal of DOI: 10.1007/s00232001095 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review The b-Cell K Channel ATP S.J.H. Ashcroft Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK Received: 3 April 2000/Revised: 8 May 2000 Introduction secretion (Ashcroft et al., 1993). A related sulfonamide, diazoxide (Loubatie `res et al., 1966), on the other hand, which hyperpolarizes the b-cell and thereby inhibits in- Insulin secretion from the pancreatic b-cell is regulated sulin secretion, is used to treat the hyperinsulinemia aris- by changes in blood glucose concentration and an inte- ing from excessive insulin secretion (Dunne, Aynsley- grated network of hormonal, neural and paracrine signals Green & Lindley, 1997a). The story of the discovery of (Ashcroft et al., 1994; Ashcroft & Ashcroft, 1992a; Bru- these compounds has been reviewed (Loubatie `res, 1969; nicardi, Shavelle & Andersen, 1995; Smith & Bloom, Henquin, 1992; Ashcroft & Ashcroft, 1992b). Hor- 1995; D’Alessio, 1997; Prentki, Tornheim & Corkey, mones and neurotransmitters modulate the primary re- 1997). Of critical importance for initiation of secretion sponse to glucose through a variety of second messenger is the intracellular concentration of calcium ions (Woll- pathways (Berggren
The Journal of Membrane Biology – Springer Journals
Published: Aug 1, 2000
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