Psychopharmacology (2017) 234:2499–2514 DOI 10.1007/s00213-017-4637-2 ORIGINAL INVESTIGATION The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal Band β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects 1 1,2 1 3 Amy W.M. Ewald & Peter J. Bosch & Aimee Culverhouse & Rachel Saylor Crowley & 3 3 1 Benjamin Neuenswander & Thomas E. Prisinzano & Bronwyn M. Kivell Received: 31 May 2016 /Accepted: 5 May 2017 /Published online: 23 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract activity, open arm times (EPM) or swimming behaviours Rationale Kappa-opioid receptor (KOPr) agonists have (FST) were seen with EOM (0.1 or 0.3 mg/kg, i.p.) or pre-clinical anti-cocaine and analgesic effects. However, side β-THP Sal B (1 or 2 mg/kg, i.p.). However, β-THP Sal B effects including sedation, dysphoria, aversion, anxiety and decreased time spent in the drug-paired chamber. depression limit their therapeutic development. The unique Conclusion EOM Sal B is more potent than Sal A and β-THP structure of salvinorin A has been used to develop longer Sal B in reducing drug-seeking behaviour with fewer side acting KOPr agonists. effects. EOM Sal B showed no effects on sucrose Objectives We evaluate two novel C-2 analogues of self-administration (0.1 mg/kg), locomotor, depressive-like, salvinorin
Psychopharmacology – Springer Journals
Published: May 23, 2017
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