Mammalian Genome 10, 197–200 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 1 3 1,2 Philip J. Gage, Hoonkyo Suh, Sally A. Camper Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109-0638, USA Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0638, USA Graduate Program in Neuroscience, University of Michigan Medical School, Ann Arbor, MI 48109-0638, USA Received: 18 August 1998 / Accepted: 11 November 1998 The important roles of homeobox genes in development of the residue 50 within the homeodomain. This residue, at residue 9 hindbrain and axial body are well established. More recently, it has within the recognition helix of the homeodomain, is the major become clear that certain subfamilies of homeobox genes play determinant of DNA binding specificity (Gehring et al., 1994; particularly important roles in the development of more anterior Hanes and Brent, 1989). Several members of this small subfamily structures. These have included the paired gene family in the eye are essential for axis and pattern formation (Ang et al., 1996). (Gehring, 1996; Hanson and Van Heyningen, 1995; Macdonald Pitx2 expresses multiple protein isoforms as a result of alternative and Wilson, 1996; Wehr and
Mammalian Genome – Springer Journals
Published: Feb 1, 1999
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