Curr Stem Cell Rep (2017) 3:156–163 DOI 10.1007/s40778-017-0085-5 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche 1 1 1 Negar Seyedhassantehrani & Takayoshi Otsuka & Shambhavi Singh & David M. Gardiner Published online: 27 July 2017 Springer International Publishing AG 2017 Abstract bioinspired, biomimetic materials to create a dynamic stem Purpose of Review Recent advances in genomics and gene cell niche for regeneration and scar-free repair. editing have expanded the range of model organisms to in- . . clude those with interesting biological capabilities such as Keywords Axolotl Regeneration Regenerative . . . regeneration. Among these are the classic models of regener- engineering Hyaluronic acid Heparan sulfate ECM ation biology, the salamander. Although stimulating endoge- nous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering Introduction (e.g., bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching Historically, model systems for studying developmental biology the problem from an engineering perspective. The question were limited to organisms with amenable genetics. These ani- at this point
Current Stem Cell Reports – Springer Journals
Published: Jul 27, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud