The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche

The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche Curr Stem Cell Rep (2017) 3:156–163 DOI 10.1007/s40778-017-0085-5 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche 1 1 1 Negar Seyedhassantehrani & Takayoshi Otsuka & Shambhavi Singh & David M. Gardiner Published online: 27 July 2017 Springer International Publishing AG 2017 Abstract bioinspired, biomimetic materials to create a dynamic stem Purpose of Review Recent advances in genomics and gene cell niche for regeneration and scar-free repair. editing have expanded the range of model organisms to in- . . clude those with interesting biological capabilities such as Keywords Axolotl Regeneration Regenerative . . . regeneration. Among these are the classic models of regener- engineering Hyaluronic acid Heparan sulfate ECM ation biology, the salamander. Although stimulating endoge- nous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering Introduction (e.g., bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching Historically, model systems for studying developmental biology the problem from an engineering perspective. The question were limited to organisms with amenable genetics. These ani- at this point http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Stem Cell Reports Springer Journals

The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Life Sciences; Cell Biology; Stem Cells
eISSN
2198-7866
D.O.I.
10.1007/s40778-017-0085-5
Publisher site
See Article on Publisher Site

Abstract

Curr Stem Cell Rep (2017) 3:156–163 DOI 10.1007/s40778-017-0085-5 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche 1 1 1 Negar Seyedhassantehrani & Takayoshi Otsuka & Shambhavi Singh & David M. Gardiner Published online: 27 July 2017 Springer International Publishing AG 2017 Abstract bioinspired, biomimetic materials to create a dynamic stem Purpose of Review Recent advances in genomics and gene cell niche for regeneration and scar-free repair. editing have expanded the range of model organisms to in- . . clude those with interesting biological capabilities such as Keywords Axolotl Regeneration Regenerative . . . regeneration. Among these are the classic models of regener- engineering Hyaluronic acid Heparan sulfate ECM ation biology, the salamander. Although stimulating endoge- nous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering Introduction (e.g., bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching Historically, model systems for studying developmental biology the problem from an engineering perspective. The question were limited to organisms with amenable genetics. These ani- at this point

Journal

Current Stem Cell ReportsSpringer Journals

Published: Jul 27, 2017

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