The Association Between Weight Loss and Quality of Life 1 and 5 Years
After Laparoscopic Roux-en-Y Gastric Bypass in Danish Bariatric Patients
Maria Biehl Gustafson
Jens Fromholt Larsen
Published online: 22 December 2017
Springer Science+Business Media, LLC, part of Springer Nature 2017
Background Laparoscopic Roux-en-Y gastric bypass (LRYGB) is effective to achieve significant weight loss, as well as im-
provement of comorbidity and quality of life (QoL) in obese patients. Several studies have examined whether weight loss can
predict the change in QoL after LRYGB but results vary and follow-up is short. The aim of this study was to examine the
association between weight loss and change in QoL at 1- and 5-year follow-up after LRYGB.
Methods The study was a cohort study with 1- and 5-year follow-up, based on data consecutively recorded at the Private Hospital
Mølholm, Denmark. Before LRYGB (baseline), 3371 severely obese patients filled in the questionnaire that included information
on weight and QoL. The patients were invited to fill in a similar questionnaire at 1- and at 5-year follow-up. The response rate at 1
and 5 years was 71 and 63%, respectively.
Results Among the respondents, there was a positive, significant association between weight loss and change in QoL at both 1-
and 5-year follow-up after LRYGB. Weight loss and change in QoL peaked after 1 year but remained significantly different from
baseline at 5-year follow-up.
Conclusion This study showed that weight loss after LRYGB predicts the change in QoL of patients 1 and 5 years after surgery.
Furthermore, both weight loss and change in QoL peaked after 1 year but remained significant at 5-year follow-up.
Laparoscopic Roux-en-Y gastric bypass
Quality of life
Since 1980, the prevalence of obesity has more than doubled
worldwide and is now considered a global epidemic. Obesity
leads to an increased risk of comorbidity, depression and re-
duced quality of life (QoL) [1, 2].
Surgical intervention in obesity is the only evidence-based
treatment to obtain sustained long-term weight loss and thus
reduction of comorbidities. Laparoscopic Roux-en-Y gastric
bypass (LRYGB) is one of the most effective bariatric proce-
dures to ensure long-term weight loss. According to the
Danish Obesity Surgery Registry, LRYGB is the most com-
mon bariatric surgical procedure in Denmark . Studies have
shown that LRYGB results in a massive weight loss and im-
provement in QoL [3–5]. To achieve the best possible out-
come, it is of great importance to determine the factors
predicting change in QoL after LRYGB. Studies have exam-
ined the association between change in weight and change in
QoL after LRYGB, but results vary [4–7]. The studies exam-
ining weight loss and QoL are small studies with short follow-
up [5, 7–9]. Moreover, the literature lacks studies on weight
loss and QoL in a Danish context. The aim of this study was to
investigate the association between change in weight and
change in QoL 1 and 5 years after LRYGB in a cohort of
severely obese patients operated at a Danish private hospital.
In addition, this study aimed to analyse trends in weight and
QoL after LRYGB in the same cohort.
* Maria Biehl Gustafson
Department of Orthopaedic Surgery, Aarhus University Hospital,
Tage-Hansens Gade 2, DK-8000 Aarhus C, Denmark
Department of Physiotherapy and Occupational Therapy, Aarhus
University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark
Centre of Research in Rehabilitation (CORIR), Department of
Clinical Medicine, Aarhus University Hospital and Aarhus
University, Aarhus, Denmark
Department of Bariatric Surgery, Mølholm Private Hospital,
Obesity Surgery (2018) 28:1622–1628