The Association Between Salivary Hormone Levels and Children’s Inpatient Aggression: A Pilot Study

The Association Between Salivary Hormone Levels and Children’s Inpatient Aggression: A Pilot Study Aggression is a common management problem for child psychiatry hospital units. We describe an exploratory study with the primary objective of establishing the feasibility of linking salivary concentrations of three hormones (testosterone, dehydroepiandrosterone [DHEA], and cortisol) with aggression. Between May 2011 and November 2011, we recruited 17 psychiatrically hospitalized boys (age 7–9 years). We administered the Brief Rating of Aggression by Children and Adolescents (BRACHA) and Predatory-Affective Aggression Scale (PAAS) upon admission. Saliva samples were collected from the participants during a 24-h period shortly after admission: immediately upon awakening, 30 min later, and again between 3:45 and 7:45 P.M. Nursing staff recorded Overt Aggression Scale ratings twice a day during hospitalization to quantify aggressive behavior. The salivary cortisol concentrations obtained from aggressive boys 30 min after awakening trended higher than levels from the non-aggressive boys (p = 0.06), were correlated with the number of aggressive incidents (p = 0.04), and trended toward correlation with BRACHA scores (p = 0.06). The aggressive boys also showed greater morning-to-evening declines in cortisol levels (p = 0.05). Awakening levels of DHEA and testosterone were correlated with the severity of the nearest aggressive incident (p < 0.05 for both). The BRACHA scores of the aggressive boys were significantly higher than scores of the non-aggressive boys (p < 0.001). Our data demonstrate the feasibility of collecting saliva from children on an inpatient psychiatric unit, affirm the utility of the BRACHA in predicting aggressive behavior, and suggest links between salivary hormones and aggression by children who undergo psychiatric hospitalization. Psychiatric Quarterly Springer Journals

The Association Between Salivary Hormone Levels and Children’s Inpatient Aggression: A Pilot Study

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Springer US
Copyright © 2013 by Springer Science+Business Media New York
Medicine & Public Health; Psychiatry; Public Health; Sociology, general
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  • Salivary testosterone determination in studies of child health and development
    Granger, DA; Schwartz, EB; Booth, A; Arentaz, M
  • Salivary cortisol and aggression in a population-based longitudinal study of adolescent males
    Bokhoven, I; Goozen, SHM; Engeland, H; Schaal, B; Arseneault, L; Séguin, JR; Nagin, DS; Vitaro, F; Tremblay, RE

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