Purpose Several studies investigated the association between the estimated glomerular filtration rate (eGFR) and the con - centration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure. Methods We enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We 2 2 grouped them based on their eGFR into: group 1 (≥ 30 < 60 ml/min/1.73 m ), group 2 (≥ 60 < 90 ml/min/1.73 m ) and group 3 (≥ 90 ml/min/1.73 m ). We analyzed the difference between their HDL levels and assessed the association of HDL and eGFR in three regression models with the following predictors: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus excessive weight and obesity, hypertension, hypercholes- terolemia, hypertriglyceridemia, family history of CVD and medications they used). Results Patients with the lowest eGFR had the lowest HDL values (P = 0.013). In multiple linear regression, HDL was an independent predictor of eGFR (β = 0.189, P = 0.025)
International Urology and Nephrology – Springer Journals
Published: Mar 28, 2018
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