The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease

The association between high-density lipoproteins and estimated glomerular filtration rate in... Purpose Several studies investigated the association between the estimated glomerular filtration rate (eGFR) and the con - centration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure. Methods We enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We 2 2 grouped them based on their eGFR into: group 1 (≥ 30 < 60 ml/min/1.73 m ), group 2 (≥ 60 < 90 ml/min/1.73 m ) and group 3 (≥ 90 ml/min/1.73 m ). We analyzed the difference between their HDL levels and assessed the association of HDL and eGFR in three regression models with the following predictors: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus excessive weight and obesity, hypertension, hypercholes- terolemia, hypertriglyceridemia, family history of CVD and medications they used). Results Patients with the lowest eGFR had the lowest HDL values (P = 0.013). In multiple linear regression, HDL was an independent predictor of eGFR (β = 0.189, P = 0.025) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Urology and Nephrology Springer Journals

The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media B.V., part of Springer Nature
Subject
Medicine & Public Health; Nephrology; Urology
ISSN
0301-1623
eISSN
1573-2584
D.O.I.
10.1007/s11255-018-1851-8
Publisher site
See Article on Publisher Site

Abstract

Purpose Several studies investigated the association between the estimated glomerular filtration rate (eGFR) and the con - centration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure. Methods We enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We 2 2 grouped them based on their eGFR into: group 1 (≥ 30 < 60 ml/min/1.73 m ), group 2 (≥ 60 < 90 ml/min/1.73 m ) and group 3 (≥ 90 ml/min/1.73 m ). We analyzed the difference between their HDL levels and assessed the association of HDL and eGFR in three regression models with the following predictors: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus excessive weight and obesity, hypertension, hypercholes- terolemia, hypertriglyceridemia, family history of CVD and medications they used). Results Patients with the lowest eGFR had the lowest HDL values (P = 0.013). In multiple linear regression, HDL was an independent predictor of eGFR (β = 0.189, P = 0.025)

Journal

International Urology and NephrologySpringer Journals

Published: Mar 28, 2018

References

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