In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathways have been explored to be essential in the development of cardiovascular diseases, their clinical significances are still uncertain. With the emergence of induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular diseases has been established to model cardiovascular diseases on specific genetic background in vitro. This review summarizes current progresses of iPSCs in cardiovascular disease modeling and drug testing. This review highlighted iPSC-based cardiovascular disease modeling and drug testing. The technical advances in iPSC-based researches and various clinically relevant applications are discussed. With further intensive research, iPSC technology will shape the future of clinical translational research in cardiovascular diseases. . . . Keywords Induced pluripotent stem cells Cardiovascular diseases Disease modeling Drug testing Introduction of iPSCs ability of animal models to predict their efficacy, safety, and toxicity in human. Due to intrinsic and different Cardiovascular diseases are considered as the leading genetic backgrounds between humans and other species, cause of human death all over the world. Despite of it is urgent to establish human-based specific
Journal of Cardiovascular Translational Research – Springer Journals
Published: May 29, 2018
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