Eur J Clin Pharmacol (2017) 73:1173–1179 DOI 10.1007/s00228-017-2281-8 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION The antipsychotic agent quetiapine is increasingly not used as such: dispensed prescriptions in Norway 2004–2015 1 2 3 4,5 Pål Gjerden & Jørgen G. Bramness & Ingunn Fride Tvete & Lars Slørdal Received: 26 January 2017 /Accepted: 7 June 2017 /Published online: 16 June 2017 Springer-Verlag GmbH Germany 2017 Abstract treatment of a major psychiatric disorder and only 2.6% of the Purpose The antipsychotic agent quetiapine was introduced patients were prescribed 1 DDD or more per day and reim- in Norway in 2003. We have assessed changes in dispensed bursed in accordance with the drug’s primary indication, psy- prescriptions, including dosing, of quetiapine in Norway from chosis. A reported diagnosis of psychosis was not associated 2004 to 2015. with higher quetiapine doses. Methods Data on the sales of antipsychotics and antidepres- Conclusions In 2015, the pattern of quetiapine dispensing in sants were drawn from the Norwegian Prescription Database. Norway most likely reflects predominant off-label use. This is A total of 47,474 outpatients filled 195,622 prescriptions of unsettling considering poorly documented effects in non- quetiapine. Reimbursement codes, use of antipsychotics or psychotic disorders, profound side effects, significant toxicity antidepressants
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 16, 2017
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