Russian Journal of Genetics, Vol. 38, No. 3, 2002, pp. 343–344. Translated from Genetika, Vol. 38, No. 3, 2002, pp. 431–432. Original Russian Text Copyright © 2002 by Omel’yanchuk. CHRONICLE The 2001 Nobel Prize in Physiology and Medicine Is Awarded for Advances in Studying the Cell Cycle Leland Hartwell (United States), Timothy Hunt gene is 63% homologous to the aforementioned cdc28 (United Kingdom), and Paul Nurse (United Kingdom) gene of S. cerevisiae and may be functionally replaced shared the Nobel Prize for Key Regulators of the Cell by the latter. More detailed studies demonstrated that Cycle. The cell cycle is a sequence of the phases G1 cdc2 is also involved in the control of the G1–S transi- (when each one of homologous chromosomes exists as tion. According to the new nomenclature, the mamma- a single copy), S (when sister chromatids are synthe- lian homolog of the cdc2 gene and its product are des- sized), G2 (when the synthesis of sister chromatids is ignated cdk1 and p34, respectively. completed), and M (mitosis, when the division spindle Studies performed by T. Hunt represent another line is formed and chromosome disjunction occurs). of research in the regulation of the cell cycle. Two
Russian Journal of Genetics – Springer Journals
Published: Oct 13, 2004
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