The 100 most-cited articles in Parkinson’s disease
Received: 6 December 2017 /Accepted: 13 May 2018
Springer-Verlag Italia S.r.l., part of Springer Nature 2018
Background Parkinson’s disease (PD), the second most common neurodegenerative disease, has serious clinical effects.
Research on PD is increasing, but the quantity and quality of this research have not been reported.
Methods To analyze the most-cited articles on PD and provide information about developments in this field, we searched for
articles in the Web of Science for the keyword BParkinson*^ in the title. We selected the 100 most-cited articles and evaluated
information including citation number, publication time, journal, impact factor, authors, original country, institution of corre-
sponding author, and study type.
Results Citation numbers for the 100 most-cited articles ranged from 669 to 6902, with a median of 944. The 100 articles were
published from 1967 to 2009, with most appearing between 1996 and 2000 (n = 24) and 2001 to 2005 (n = 27). The publications
appeared in a total of 31 journals, led by Science with 15 and the New England Journal of Medicine (NEJM) with 13. The
majority (84%) of the 100 most-cited articles had ≥ 3 authors. The articles originated from 14 countries, led by the USA (n =44)
and England (n = 17). Among the 100 most-cited articles, 24 were clinical studies, 54 were laboratory studies, 20 were reviews,
and 2 were clinical guidelines. None of these articles originated from South America, Oceania, or Africa.
Conclusions The present study provides historical perspectives on the progress of PD research and highlights trends and aca-
demic achievements in this field.
Parkinson’s disease (PD) is the second-most prevalent neuro-
degenerative disease which characterized by the progressive
loss of dopaminergic neurons in the substantia nigra pars
compacta [1, 2]. It is a major contributor to worsened medical
outcomes, poor quality of life, disability, and nursing home
placement [3, 4]. Medical researchers have increasingly ex-
plored the mechanisms, early recognition, and prevention of
PD. However, the PD research literature has not been ana-
lyzed to assess the quality of scientific insights in this area.
Citation analysis is an important method for determining
the influence of an article on scientific progress as well as
evaluating the impact factor (IF) of a scientific journal .
The study of citation analysis may help to identify articles,
research topics, and authors of influence.. Attempts have
been made to identify the most cited articles in many fields,
including neurosurgery,, traumatic brain injury , ortho-
pedics , radiology , and surgery . However, no
citation analysis of PD has been published. Therefore, we
analyzed and characterized the 100 most-cited articles on
PD, to obtain an indication of the most impactful advances,
developments, and discoveries in this field during the past
Jin-hua Xue, Zhi-ping Hu and Ping Lai contributed equally to this work.
Electronic supplementary material The online version of this article
(https://doi.org/10.1007/s10072-018-3450-y) contains supplementary
material, which is available to authorized users.
* De-qing Cai
* Er-sheng Wen
Department of Physiology, School of Basic Medical Sciences,
Gannan Medical University, Ganzhou 341000, China
Department of Cardiology, the First Affiliated Hospital of Gannan
Medical University, Ganzhou 341000, China
Department of Library and Information Center, Gannan Medical
University, Ganzhou 341000, China