Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats

Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the... Psychopharmacology (2017) 234:2399–2407 DOI 10.1007/s00213-017-4627-4 ORIGINAL INVESTIGATION Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats 1 2 3 1 Jasjot Saund & Daniel Dautan & Claire Rostron & Gonzalo P. Urcelay & Todor V. Gerdjikov Received: 28 July 2016 /Accepted: 7 April 2017 /Published online: 28 April 2017 The Author(s) 2017. This article is an open access publication Abstract responses or response accuracy, even under increased atten- Rationale Corticostriatal circuits are widely implicated in the tional load. Control experiments showed no effects on loco- top-down control of attention including inhibitory control and motor activity in an open field. behavioural flexibility. However, recent neurophysiological Conclusions These results complement previous lesion work evidence also suggests a role for thalamic inputs to striatum in which the DMS and orbitofrontal cortex were similarly in behaviours related to salient, reward-paired cues. implicated in perseverative responses and suggest a specific Objectives Here, we used designer receptors exclusively acti- role for thalamostriatal inputs in inhibitory control. vated by designer drugs (DREADDs) to investigate the role of . . parafascicular (Pf) thalamic inputs to the dorsomedial striatum Keywords Thalamostriatal pathway Dorsomedial striatum (DMS) using the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4627-4
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2399–2407 DOI 10.1007/s00213-017-4627-4 ORIGINAL INVESTIGATION Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats 1 2 3 1 Jasjot Saund & Daniel Dautan & Claire Rostron & Gonzalo P. Urcelay & Todor V. Gerdjikov Received: 28 July 2016 /Accepted: 7 April 2017 /Published online: 28 April 2017 The Author(s) 2017. This article is an open access publication Abstract responses or response accuracy, even under increased atten- Rationale Corticostriatal circuits are widely implicated in the tional load. Control experiments showed no effects on loco- top-down control of attention including inhibitory control and motor activity in an open field. behavioural flexibility. However, recent neurophysiological Conclusions These results complement previous lesion work evidence also suggests a role for thalamic inputs to striatum in which the DMS and orbitofrontal cortex were similarly in behaviours related to salient, reward-paired cues. implicated in perseverative responses and suggest a specific Objectives Here, we used designer receptors exclusively acti- role for thalamostriatal inputs in inhibitory control. vated by designer drugs (DREADDs) to investigate the role of . . parafascicular (Pf) thalamic inputs to the dorsomedial striatum Keywords Thalamostriatal pathway Dorsomedial striatum (DMS) using the

Journal

PsychopharmacologySpringer Journals

Published: Apr 28, 2017

References

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