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R. Ohlsson, E. Larsson, O. Nilsson, T. Wahlstrom, Per Sundstrōm (1989)
Blastocyst implantation precedes induction of insulin-like growth factor II gene expression in human trophoblasts.Development, 106 3
T. Dechiara, E. Robertson, A. Efstratiadis (1991)
Parental imprinting of the mouse insulin-like growth factor II geneCell, 64
W. Reik, J. Walter (2001)
Genomic imprinting: parental influence on the genomeNature Reviews Genetics, 2
Thomas Harris, L. Rogler, C. Rogler (1998)
Reactivation of the maternally imprinted IGF2 allele in TGFα induced hepatocellular carcinomas in miceOncogene, 16
Charles RoglerSS, Deyun YangS, Lucian Rossettin, Jeff DonohoeS, Elaine AltSll, Chee-Jen Chang, Ron RosenfeldSS, Kirk NeelySS, Ray HintzSS (1994)
Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.The Journal of biological chemistry, 269 19
K. Brown, A. Villar, W. Bickmore, J. Clayton-Smith, D. Catchpoole, E. Maher, W. Reik (1996)
Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Human molecular genetics, 5 12
E. Platonov, L. Penkov, D. New (2004)
Effects of Growth Factors FGF2 and IGF2 on the Development of Parthenogenetic Mouse Embryos in utero and in vitroRussian Journal of Developmental Biology, 33
P. Rotwein, Lisa Hall (1990)
Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons.DNA and cell biology, 9 10
T. Kono, Y. Obata, Quiong Wu, K. Niwa, Y. Ono, Yuji Yamamoto, Eun Park, Jeong-Sun Seo, H. Ogawa (2004)
Birth of parthenogenetic mice that can develop to adulthoodNature, 428
(1995)
Transform - ing Growth Factors α and β Expression in Fertilized and Parthenogenetic PreImplantation Mouse Embryos : RNA Detection with Fluorescent In Situ Hybridization
M. Constância, B. Pickard, G. Kelsey, W. Reik (1998)
Imprinting mechanisms.Genome research, 8 9
A. Ferguson-Smith, M. Surani (2001)
Imprinting and the Epigenetic Asymmetry Between Parental GenomesScience, 293
F. Sleutels, D. Barlow (2002)
The origins of genomic imprinting in mammals.Advances in genetics, 46
E. Platonov, L. Penkov, B. Konyukhov (2001)
Transforming Growth Factor α (TGFα) Modulates the Effects of Genomic Imprinting and Prolongs Development of Parthenogenetic Mouse EmbryosRussian Journal of Genetics, 37
(2001)
Transforming Growth Factor α (TGFα) Modulates the Effect of Genomic Imprinting and Prolongs the Development of Parthenogenetic Murine Embryos, Russ
D. Barlow (1997)
Competition—a common motif for the imprinting mechanism?The EMBO Journal, 16
T. Dechiara, A. Efstratiadis, Elizabeth Robertsen (1990)
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targetingNature, 345
M. Constância, M. Hemberger, J. Hughes, W. Dean, A. Ferguson-Smith, R. Fundele, F. Stewart, G. Kelsey, A. Fowden, C. Sibley, W. Reik (2002)
Placental-specific IGF-II is a major modulator of placental and fetal growthNature, 417
E. Platonov, L. Penkov, B. Koniukhov (2001)
[Transforming growth factor alpha (TGFalpha) modulates the effect of genomic imprinting and prolongs the development of parthenogenetic murine embryos].Genetika, 37 10
M. Constância, W. Dean, Susana Lopes, T. Moore, G. Kelsey, W. Reik (2000)
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19Nature Genetics, 26
J. Joyce, W. Lam, W. Lam, D. Catchpoole, Paul Jenks, W. Reik, E. Maher, E. Maher, P. Schofield (1997)
Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith-Wiedemann syndrome.Human molecular genetics, 6 9
A. Roberts, URSULA Heine, K. Flanders, M. Sporn (1990)
Transforming Growth Factor‐βAnnals of the New York Academy of Sciences, 580
P. Pagter-Holthuizen, M. Jansen, R. Kammen, F. Schaik, J. Sussenbach (1988)
Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.Biochimica et biophysica acta, 950 3
J. Ainscough, Rosalind John, S. Barton, M. Surani (2000)
A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene.Development, 127 18
T. Vu, A. Hoffman (1994)
Promoter-specific imprinting of the human insulin-like growth factor-II geneNature, 371
C. Brannan, Marisa Bartolomei (1999)
Mechanisms of genomic imprinting.Current opinion in genetics & development, 9 2
S. Croteau, Y. Ménézo, M. Benkhalifa (1995)
Transforming growth factors‐α and ‐β expression in fertilized and parthenogenetic pre‐implantation mouse embryos: RNA detection with fluorescent in situ hybridizationDevelopment, 37
F. Sleutels, D. Barlow (2002)
5 The origins of genomic imprinting in mammalsAdvances in Genetics, 46
E. Putnam, N. Yen, G. Gallick, P. Steck, K. Fang, B. Akpakip, A. Gazdar, J. Roth (1992)
Autocrine growth stimulation by transforming growth factor-α in human non-small cell lung cancerSurgical Oncology-oxford, 1
Imprinted genes play important roles in the mammalian development. In the parthenogenetic embryos (PE), there is only expression of maternally expressed genes. Therefore, PEs are appropriate experimental models to study genomic imprinting controlling mechanisms. The maternally expressed H19 and paternally expressed Igf2 are reciprocally imprinted genes in normal embryos. Here, we studied effect of transforming growth factor alpha (TGFα) treatment in vitro (10 ng/ml at the morula stage) on the expression of Igf2/H19 locus in mice PE (9.5 days of gestation, 25 somites) and their placentas (PP). Using RT-PCR, we showed that TGFα reactivated maternally imprinted Igf2 gene in parthenogenetic embryos and placentas. In spite of similar Tgfα expression in the preimplantation stages, its expression in the 9.5-day parthenogenetic embryos is significantly less than in normal embryos (NE). In our experiments, it was shown that reactivation of Igf2 gene occurred independently of H19 gene. In vitro TGFα treatment of mouse PE reactivated paternally expressed Igf2 gene in the PE and PP. In the PE and PP, both Igf2 and H19 were expressed. It seems that TGFα can play an important role as modulator of the Igf2/H19 locus.
Russian Journal of Genetics – Springer Journals
Published: Nov 11, 2005
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