ORIGINAL ARTICLE Test–retest repeatability of myocardial oxidative metabolism and efﬁciency using standalone dynamic C-acetate PET and multimodality approaches in healthy controls a b Nils Henrik Hansson, MD, PhD, Hendrik Johannes Harms, PhD, a a b Won Yong Kim, MD, DMSc, Roni Nielsen, MD, PhD, Lars P. Tolbod, PhD, b b Jørgen Frøkiær, MD, DMSc, Kirsten Bouchelouche, MD, DMSc, a a Steen Hvitfeldt Poulsen, MD, DMSc, Henrik Wiggers, MD, DMSc, c b Erik Thorlund Parner, PhD, and Jens So¨rensen, MD, DMSc Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark Received Jan 16, 2018; accepted Apr 25, 2018 doi:10.1007/s12350-018-1302-z Background. Myocardial efﬁciency measured by C-acetate positron emission tomography (PET) has successfully been used in clinical research to quantify mechanoenergetic coupling. The objective of this study was to establish the repeatability of myocardial external efﬁciency (MEE) and work metabolic index (WMI) by non-invasive concepts. Methods and Results. Ten healthy volunteers (63 ± 4 years) were examined twice, one week apart, using C-acetate PET, cardiovascular magnetic resonance (CMR), and echocardiog- raphy. Myocardial oxygen consumption from PET was combined with stroke work
Journal of Nuclear Cardiology – Springer Journals
Published: May 31, 2018
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