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Test–retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic 11C-acetate PET and multimodality approaches in healthy controls

Test–retest repeatability of myocardial oxidative metabolism and efficiency using standalone... ORIGINAL ARTICLE Test–retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic C-acetate PET and multimodality approaches in healthy controls a b Nils Henrik Hansson, MD, PhD, Hendrik Johannes Harms, PhD, a a b Won Yong Kim, MD, DMSc, Roni Nielsen, MD, PhD, Lars P. Tolbod, PhD, b b Jørgen Frøkiær, MD, DMSc, Kirsten Bouchelouche, MD, DMSc, a a Steen Hvitfeldt Poulsen, MD, DMSc, Henrik Wiggers, MD, DMSc, c b Erik Thorlund Parner, PhD, and Jens So¨rensen, MD, DMSc Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark Received Jan 16, 2018; accepted Apr 25, 2018 doi:10.1007/s12350-018-1302-z Background. Myocardial efficiency measured by C-acetate positron emission tomography (PET) has successfully been used in clinical research to quantify mechanoenergetic coupling. The objective of this study was to establish the repeatability of myocardial external efficiency (MEE) and work metabolic index (WMI) by non-invasive concepts. Methods and Results. Ten healthy volunteers (63 ± 4 years) were examined twice, one week apart, using C-acetate PET, cardiovascular magnetic resonance (CMR), and echocardiog- raphy. Myocardial oxygen consumption from PET was combined with stroke work http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Nuclear Cardiology Springer Journals

Test–retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic 11C-acetate PET and multimodality approaches in healthy controls

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Publisher
Springer Journals
Copyright
Copyright © 2018 by American Society of Nuclear Cardiology
Subject
Medicine & Public Health; Cardiology; Nuclear Medicine; Imaging / Radiology
ISSN
1071-3581
eISSN
1532-6551
DOI
10.1007/s12350-018-1302-z
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Test–retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic C-acetate PET and multimodality approaches in healthy controls a b Nils Henrik Hansson, MD, PhD, Hendrik Johannes Harms, PhD, a a b Won Yong Kim, MD, DMSc, Roni Nielsen, MD, PhD, Lars P. Tolbod, PhD, b b Jørgen Frøkiær, MD, DMSc, Kirsten Bouchelouche, MD, DMSc, a a Steen Hvitfeldt Poulsen, MD, DMSc, Henrik Wiggers, MD, DMSc, c b Erik Thorlund Parner, PhD, and Jens So¨rensen, MD, DMSc Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark Received Jan 16, 2018; accepted Apr 25, 2018 doi:10.1007/s12350-018-1302-z Background. Myocardial efficiency measured by C-acetate positron emission tomography (PET) has successfully been used in clinical research to quantify mechanoenergetic coupling. The objective of this study was to establish the repeatability of myocardial external efficiency (MEE) and work metabolic index (WMI) by non-invasive concepts. Methods and Results. Ten healthy volunteers (63 ± 4 years) were examined twice, one week apart, using C-acetate PET, cardiovascular magnetic resonance (CMR), and echocardiog- raphy. Myocardial oxygen consumption from PET was combined with stroke work

Journal

Journal of Nuclear CardiologySpringer Journals

Published: May 31, 2018

References