Pathol. Oncol. Res. (2018) 24:697–698 DOI 10.1007/s12253-017-0275-6 LETTER TO THE EDITOR TERT Promoter Mutation and Telomere Length in Salivary Gland Tumors 1,2 1 1 3 4 Heejin Kim & Dongbin Ahn & Jin Ho Sohn & Yong-Hee Kim & Jae-Ho Lee & Hyunsu Lee Received: 7 February 2017 /Accepted: 22 June 2017 /Published online: 29 June 2017 Arányi Lajos Foundation 2017 To editor has been barely investigated telomere related tumorigen- Telomeres are well known structure that protects the esis mechanism including shortening length of telomere ends of chromosomes from end-to-end fusion and con- and the mutation in the promoter region of TERT. tribute the stability of the chromosomes. Telomerase re- In Korean population, the incidence of the salivary malig- verse transcriptase (TERT), which is subunit of telome- nancy was 0.9 cases per 100,000 population in 2013, which is rase, maintains the length of telomeres. Recently, the only 0.2% of all malignancies and about 15% of cancers of the somatic mutation in the promoter region of αTERT head and neck . Because of its rarity, little is known about were reported in various tumors including melanoma the molecular profiles of the salivary tumor. In this study, thus, [1, 2], gastric
Pathology & Oncology Research – Springer Journals
Published: Jun 29, 2017
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