Terpenoids from Tripterygium hypoglaucum and Their Anti-Inflammatory Activity

Terpenoids from Tripterygium hypoglaucum and Their Anti-Inflammatory Activity DOI 10.1007/s10600-018-2381-4 Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 TERPENOIDS FROM Tripterygium hypoglaucum AND THEIR ANTI-INFLAMMATORY ACTIVITY Qun Zhao, Hong-Mei Li, Xuan-Qin Chen, Rong-Tao Li, and Dan Liu* A new diterpenoid, 19-O--D-glucopyranosyl-labda-8(17),14-dien-13-ol (1), and nine known triterpenes (2–10) were isolated from the aerial parts of Tripterygium hypoglaucum. All structures were elucidated by NMR spectroscopic methods. Moreover, the inhibition of superoxide anion generation and elastase release were also examined. Keywords: Tripterygium hypoglaucum, Celastraceae, diterpenoid, anti-inflammatory. The genus Tripterygium (Celastraceae) includes three species: Tripterygium wilfordii Hook. f., Tripterygium hypoglaucum (Levl.) Hutch, and Tripterygium regelii Sprague et Takeda [1]. The principal chemical constituents of Tripterygium are diterpene, triterpene, and sesquiterpene alkaloids, and there are also flavonoids, steroids, tannins, and glucides in it [2]. A number of terpenoids isolated from Tripterygium plants, which modulate the production of interferon gamma (IFN-), IL-1, 2, 4, 8, and TNF- [3–7], exhibit anti-inflammatory and immunosuppressive activities. T. hypoglaucum and T. wilfordii, two morphologically similar species from this genus, have been used for many years in traditional Chinese medicine for the treatment of swelling, inflammation, cancer, rheumatoid arthritis, and as insecticides [8]. In order to discover more structurally interesting and anti-inflammatory secondary metabolites from the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Natural Compounds Springer Journals

Terpenoids from Tripterygium hypoglaucum and Their Anti-Inflammatory Activity

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Organic Chemistry; Plant Sciences
ISSN
0009-3130
eISSN
1573-8388
D.O.I.
10.1007/s10600-018-2381-4
Publisher site
See Article on Publisher Site

Abstract

DOI 10.1007/s10600-018-2381-4 Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 TERPENOIDS FROM Tripterygium hypoglaucum AND THEIR ANTI-INFLAMMATORY ACTIVITY Qun Zhao, Hong-Mei Li, Xuan-Qin Chen, Rong-Tao Li, and Dan Liu* A new diterpenoid, 19-O--D-glucopyranosyl-labda-8(17),14-dien-13-ol (1), and nine known triterpenes (2–10) were isolated from the aerial parts of Tripterygium hypoglaucum. All structures were elucidated by NMR spectroscopic methods. Moreover, the inhibition of superoxide anion generation and elastase release were also examined. Keywords: Tripterygium hypoglaucum, Celastraceae, diterpenoid, anti-inflammatory. The genus Tripterygium (Celastraceae) includes three species: Tripterygium wilfordii Hook. f., Tripterygium hypoglaucum (Levl.) Hutch, and Tripterygium regelii Sprague et Takeda [1]. The principal chemical constituents of Tripterygium are diterpene, triterpene, and sesquiterpene alkaloids, and there are also flavonoids, steroids, tannins, and glucides in it [2]. A number of terpenoids isolated from Tripterygium plants, which modulate the production of interferon gamma (IFN-), IL-1, 2, 4, 8, and TNF- [3–7], exhibit anti-inflammatory and immunosuppressive activities. T. hypoglaucum and T. wilfordii, two morphologically similar species from this genus, have been used for many years in traditional Chinese medicine for the treatment of swelling, inflammation, cancer, rheumatoid arthritis, and as insecticides [8]. In order to discover more structurally interesting and anti-inflammatory secondary metabolites from the

Journal

Chemistry of Natural CompoundsSpringer Journals

Published: Jun 7, 2018

References

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