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Angela Poole, L. Pischel, C. Ley, G. Suh, Julia Goodrich, T. Haggerty, R. Ley, J. Parsonnet (2016)
Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the MicrobiomemSphere, 1
A. Duleba, M. Ahmed, Meng Sun, A. Gao, J. Villanueva, A. Conley, J. Turgeon, K. Benirschke, N. Gee, Jiangang Chen, P. Green, B. Lasley (2011)
Effects of Triclocarban on Intact Immature Male RatReproductive Sciences, 18
Jose Navas-Molina, J. Peralta‐Sánchez, Antonio Gonzalez, Paul McMurdie, Y. Vázquez-Baeza, Z. Xu, L. Ursell, C. Lauber, Hongwei Zhou, Se Song, James Huntley, G. Ackermann, Donna berg-Lyons, S. Holmes, J. Caporaso, R. Knight (2013)
Advancing our understanding of the human microbiome using QIIME.Methods in enzymology, 531
Sandrine Claus, H. Guillou, S. Ellero-Simatos (2016)
The gut microbiota: a major player in the toxicity of environmental pollutants?NPJ Biofilms and Microbiomes, 2
J. Caporaso, Justin Kuczynski, Jesse Stombaugh, K. Bittinger, F. Bushman, E. Costello, N. Fierer, Antonio Peña, Julia Goodrich, J. Gordon, G. Huttley, S. Kelley, D. Knights, J. Koenig, R. Ley, C. Lozupone, Daniel McDonald, B. Muegge, M. Pirrung, Jens Reeder, Joel Sevinsky, P. Turnbaugh, William Walters, Jeremy Widmann, Tanya Yatsunenko, Jesse Zaneveld, R. Knight (2010)
QIIME allows analysis of high-throughput community sequencing dataNature Methods, 7
N. Mueller, Elizabeth Bakacs, Joan Combellick, Zoya Grigoryan, M. Dominguez-Bello (2015)
The infant microbiome development: mom matters.Trends in molecular medicine, 21 2
L. Scharpf, I. Hill, H. Maibach (1975)
Percutaneous penetration and disposition of triclocarban in man: body showering.Archives of environmental health, 30 1
N. Schebb, B. Inceoğlu, K. Ahn, C. Morisseau, S. Gee, B. Hammock (2011)
Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects.Environmental science & technology, 45 7
AJ Duleba, MI Ahmed, M Sun, AC Gao, J Villanueva, AJ Conley, JL Turgeon, K Benirschke, NA Gee, J Chen, PG Green, BL Lasley (2011)
Effects of triclocarban on intact immature male rat: augmentation of androgen actionReprod Sci, 18
Jiangang Chen, K. Ahn, N. Gee, M. Ahmed, A. Duleba, Ling Zhao, S. Gee, B. Hammock, B. Lasley (2008)
Triclocarban enhances testosterone action: a new type of endocrine disruptor?Endocrinology, 149 3
H. Wopereis, R. Oozeer, K. Knipping, C. Belzer, J. Knol (2014)
The first thousand days – intestinal microbiology of early life: establishing a symbiosisPediatric Allergy and Immunology, 25
T. Sweeney, J. Morton (2013)
The human gut microbiome: a review of the effect of obesity and surgically induced weight loss.JAMA surgery, 148 6
M. Arrieta, Leah Stiemsma, Nelly Amenyogbe, Eric Brown, B. Finlay (2014)
The Intestinal Microbiome in Early Life: Health and DiseaseFrontiers in Immunology, 5
Jianzhong Hu, Vincent Raikhel, Kalpana Gopalakrishnan, Heriberto Fernandez-Hernandez, L. Lambertini, F. Manservisi, L. Falcioni, L. Bua, F. Belpoggi, Susan L.Teitelbaum, Jia Chen (2016)
Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent modelMicrobiome, 4
Grace Lee, K. Reveles, R. Attridge, K. Lawson, I. Mansi, James Lewis, C. Frei (2014)
Outpatient antibiotic prescribing in the United States: 2000 to 2010BMC Medicine, 12
I. Sekirov, Shannon Russell, L. Antunes, B. Finlay (2010)
Gut microbiota in health and disease.Physiological reviews, 90 3
Paul McMurdie, S. Holmes (2013)
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census DataPLoS ONE, 8
M. Lim, H. You, H. Yoon, Bomi Kwon, Jae Lee, Sunghee Lee, Yun-Mi Song, Kayoung Lee, J. Sung, Gwangpyo Ko (2016)
The effect of heritability and host genetics on the gut microbiota and metabolic syndromeGut, 66
R. Kindt, R. Coe (2006)
Tree diversity analysis: a manual and software for common statistical methods for ecological and biodiversity studies
Rebekah Kennedy, Russell Fling, M. Robeson, A. Saxton, R. Donnell, J. Darcy, D. Bemis, Jiang Liu, Ling Zhao, Jiangang Chen (2016)
Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal RatsScientific Reports, 6
R. Prosser, L. Lissemore, E. Topp, P. Sibley (2014)
Bioaccumulation of triclosan and triclocarban in plants grown in soils amended with municipal dewatered biosolidsEnvironmental Toxicology and Chemistry, 33
B. Pycke, L. Geer, M. Dalloul, O. Abulafia, Alizee Jenck, R. Halden (2014)
Human Fetal Exposure to Triclosan and Triclocarban in an Urban Population from Brooklyn, New YorkEnvironmental Science & Technology, 48
M. Yassour, T. Vatanen, H. Siljander, A. Hämäläinen, T. Härkönen, S. Ryhänen, E. Franzosa, H. Vlamakis, C. Huttenhower, D. Gevers, E. Lander, M. Knip, R. Xavier (2015)
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stabilityScience Translational Medicine, 8
Rebekah Kennedy, P. Terry, Jiangang Chen (2016)
Triclocarban and Health: the Jury Is Still OutmSphere, 1
L. Lindheim, M. Bashir, J. Münzker, Christian Trummer, Verena Zachhuber, Bettina Leber, Angela Horvath, Thomas Pieber, Gregor Gorkiewicz, Vanessa Stadlbauer, Barbara Obermayer-Pietsch (2017)
Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot StudyPLoS ONE, 12
C. Giuliano, M. Rybak (2015)
Efficacy of Triclosan as an Antimicrobial Hand Soap and Its Potential Impact on Antimicrobial Resistance: A Focused ReviewPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 35
X. Ye, Xiaoliu Zhou, J. Furr, K. Ahn, B. Hammock, E. Gray, A. Calafat (2011)
Biomarkers of exposure to triclocarban in urine and serum.Toxicology, 286 1-3
K. Lippert, Lyudmyla Kedenko, Livio Antonielli, I. Kedenko, C. Gemeier, M. Leitner, A. Kautzky-Willer, B. Paulweber, E. Hackl (2017)
Gut microbiota dysbiosis associated with glucose metabolism disorders and the metabolic syndrome in older adults.Beneficial microbes, 8 4
N. Aryal, Dawn Reinhold (2011)
Phytoaccumulation of antimicrobials from biosolids: impacts on environmental fate and relevance to human exposure.Water research, 45 17
G. Velmurugan, T. Ramprasath, M. Gilles, K. Swaminathan, S. Ramasamy (2017)
Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes EpidemicTrends in Endocrinology & Metabolism, 28
S. Levy (2001)
Antibacterial household products: cause for concern.Emerging Infectious Diseases, 7
S. Duncan, G. Lobley, G. Holtrop, J. Ince, A. Johnstone, P. Louis, H. Flint (2008)
Human colonic microbiota associated with diet, obesity and weight lossInternational Journal of Obesity, 32
E. Zaura, B. Brandt, M. Mattos, M. Buijs, M. Caspers, M. Rashid, A. Weintraub, C. Nord, Ann Savell, Yanmin Hu, A. Coates, M. Hubank, D. Spratt, Michael Wilson, B. Keijser, W. Crielaard, Citation Zaura, Brandt Bw, T. De, Mattos Mj, Buijs Mj, Caspers Mpm, Rashid Mu, Weintraub A, Nord Ce, Savell Hu, Coates Ar, Hubank M, Spratt Da, Wilson Keijser (2015)
Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in FecesmBio, 6
J. Caporaso, C. Lauber, William Walters, Donna berg-Lyons, James Huntley, Noah Fierer, Noah Fierer, S. Owens, J. Betley, Louise Fraser, Markus Bauer, N. Gormley, Jack Gilbert, Jack Gilbert, Geoff Smith, R. Knight (2012)
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platformsThe ISME Journal, 6
Adnan Syed, Sudeshna Ghosh, N. Love, Blaise Boles (2014)
Triclosan Promotes Staphylococcus aureus Nasal ColonizationmBio, 5
A. Everard, V. Lazarevic, N. Gaïa, M. Johansson, M. Ståhlman, F. Backhed, N. Delzenne, J. Schrenzel, P. François, Patrice Cani (2014)
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesityThe ISME Journal, 8
E. Perencevich, M. Wong, A. Harris (2001)
National and regional assessment of the antibacterial soap market: a step toward determining the impact of prevalent antibacterial soaps.American journal of infection control, 29 5
J. Lankelma, C. Belzer, A. Hoogendijk, A. Vos, W. Vos, T. Poll, Joost Wiersinga (2016)
Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy AdultsClinical and Translational Gastroenterology, 7
G. Nolen, T. Dierckman (1979)
Reproduction and teratogenic studies of a 2:1 mixture of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in rats and rabbits.Toxicology and applied pharmacology, 51 3
Pajau Vangay, Tonya Ward, J. Gerber, D. Knights (2015)
Antibiotics, pediatric dysbiosis, and disease.Cell host & microbe, 17 5
Adrienne Narrowe, Munira Albuthi-Lantz, Erin Smith, Kimberly Bower, T. Roane, A. Vajda, C. Miller (2015)
Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposureMicrobiome, 3
Xiaoqin Wu, F. Ernst, J. Conkle, J. Gan (2013)
Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables.Environment international, 60
Rebekah Kennedy, F. Menn, Laura Healy, K. Fecteau, Pan Hu, Jiyoung Bae, N. Gee, B. Lasley, Ling Zhao, Jiangang Chen (2015)
Early Life Triclocarban Exposure During Lactation Affects Neonate Rat SurvivalReproductive Sciences, 22
E. Pasch, Leah Voltmer, S. Gemmell, J. Walter, K. Walton (2009)
Effects of triclosan on the normal intestinal microbiota and on susceptibility to experimental murine colitisThe FASEB Journal, 23
M. Siddiqui, Ghulam Sarwar (1999)
Antiseptics and Disinfectants: Activity, Action, and ResistanceClinical Microbiology Reviews, 12
Nicholas Bokulich, Sathish Subramanian, J. Faith, D. Gevers, J. Gordon, R. Knight, D. Mills, J. Caporaso, Gregory Caporaso (2012)
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencingNature methods, 10
H. Frederiksen, L. Aksglaede, K. Sørensen, O. Nielsen, K. Main, N. Skakkebaek, A. Juul, A. Andersson (2013)
Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS.International journal of hygiene and environmental health, 216 6
Widely used as an antimicrobial in antibacterial bar soaps, triclocarban (3,4,4′-trichlorocarbanilide; TCC) is effective against Gram-positive bacteria but shows little efficacy against Gram-negative strains, potentially altering the composition of indigenous microflora within and on the human body. To date, the consequence of continuous or previous nonprescription antimicrobial exposure from compounds in personal care products on commensal microflora is still elusive. Previous research has shown that TCC exposure during gestation and lactation induced dysbiosis of gut microbial communities among exposed dams and neonates. However, the impact of antimicrobial exposure specifically after discontinuation of the use of TCC on the gut microbiota has not been investigated. In this study, weaned Sprague Dawley rats (postnatal day, PND 22) were provided ad lib access to TCC-supplemented diet (0.2% w/w or 0.5% w/w) for 4 weeks (phase I) followed by a 4-week washout period (phase II) to determine gut microflora changes both during continuous exposure to TCC and to determine the potential rebound following TCC withdrawal. Fecal samples were collected at baseline (PND 22) prior to TCC exposure and throughout phase I and phase II. The V4 region of 16S rDNA was sequenced from extracted total fecal DNA with the MiSeq platform. Exposure to both 0.2% w/w and 0.5% w/w TCC was sufficient to alter diversity of microbiota during phase I of treatment. This effect was further prolonged into phase II, even when TCC exposure was discontinued. Collectively, these data highlight the impact of both continuous and prior TCC exposure on gut microbial ecology and shed light onto the potential long-term health risk of daily nonprescription antimicrobial personal care product use.
Environmental Science and Pollution Research – Springer Journals
Published: Mar 13, 2018
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