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Pieterjan Kayaert, G. Mooter (2012)
Is the amorphous fraction of a dried nanosuspension caused by milling or by drying? A case study with Naproxen and Cinnarizine.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81 3
R. Sengupta, S. Chakraborty, S. Bandyopadhyay, S. Dasgupta, R. Mukhopadhyay, K. Auddy, A. Deuri (2007)
A short review on rubber/clay nanocomposites with emphasis on mechanical propertiesPolymer Engineering and Science, 47
Kiichi Egami, K. Higashi, Keiji. Yamamoto, K. Moribe (2015)
Crystallization of Probucol in Nanoparticles Revealed by AFM Analysis in Aqueous Solution.Molecular pharmaceutics, 12 8
Jonghwi Lee, Jae-Kyong Choi, Chul Park (2008)
Characteristics of polymers enabling nano-comminution of water-insoluble drugs.International journal of pharmaceutics, 355 1-2
B. Eerdenbrugh, Jared Baird, L. Taylor (2010)
Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation--classification and comparison with crystallization tendency from undercooled melts.Journal of pharmaceutical sciences, 99 9
R. Surana, L. Randall, A. Pyne, N. Vemuri, R. Suryanarayanan (2003)
Determination of Glass Transition Temperature and in Situ Study of the Plasticizing Effect of Water by Inverse Gas ChromatographyPharmaceutical Research, 20
M. Malamatari, S. Somavarapu, K. Taylor, G. Buckton (2016)
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powdersExpert Opinion on Drug Delivery, 13
Jun Hu, W. Ng, Yuancai Dong, S. Shen, R. Tan (2011)
Continuous and scalable process for water-redispersible nanoformulation of poorly aqueous soluble APIs by antisolvent precipitation and spray-drying.International journal of pharmaceutics, 404 1-2
M. Lee, S. Kim, C. Ahn, J. Lee (2010)
Hydrophilic and hydrophobic amino acid copolymers for nano-comminution of poorly soluble drugs.International journal of pharmaceutics, 384 1-2
Huabing Chen, C. Khemtong, Xiangliang Yang, X.L. Chang, Jinming Gao (2011)
Nanonization strategies for poorly water-soluble drugs.Drug discovery today, 16 7-8
Marcio Nascimento, L. Souza, E. Ferreira, Edgar Zanotto (2005)
Can glass stability parameters infer glass forming abilityJournal of Non-crystalline Solids, 351
R. Werbowyj, D. Gray (1984)
Optical properties of hydroxypropyl cellulose liquid crystals. I. Cholesteric pitch and polymer concentrationMacromolecules, 17
S Kumar, D. Burgess (2014)
Wet milling induced physical and chemical instabilities of naproxen nano-crystalline suspensions.International journal of pharmaceutics, 466 1-2
M. George, I. Ghosh (2013)
Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48 1-2
A. Otte, M. Carvajal (2011)
Assessment of milling-induced disorder of two pharmaceutical compounds.Journal of pharmaceutical sciences, 100 5
M. Reufer, Alexandra Machado, Andreas Niederquell, Katharina Bohnenblust, Beat Müller, A. Völker, M. Kuentz (2014)
Introducing diffusing wave spectroscopy as a process analytical tool for pharmaceutical emulsion manufacturing.Journal of pharmaceutical sciences, 103 12
J Acad (1984)
Optical properties of hydroxypropycelluloseMacromolecules, 17
Andreas Niederquell, M. Kuentz (2014)
Biorelevant dissolution of poorly soluble weak acids studied by UV imaging reveals ranges of fractal-like kinetics.International journal of pharmaceutics, 463 1
Jared Baird, B. Eerdenbrugh, L. Taylor (2010)
A classification system to assess the crystallization tendency of organic molecules from undercooled melts.Journal of pharmaceutical sciences, 99 9
Ji-Yeun Choi, Ji-Youn Yoo, H. Kwak, B. Nam, Jonghwi Lee (2005)
Role of polymeric stabilizers for drug nanocrystal dispersionsCurrent Applied Physics, 5
Hua Yang, Fei Teng, Puxiu Wang, Bin Tian, Xia Lin, Xi Hu, Ling Zhang, Keru Zhang, Yu Zhang, Xing Tang (2014)
Investigation of a nanosuspension stabilized by Soluplus® to improve bioavailability.International journal of pharmaceutics, 477 1-2
Daniel Goodwin, S. Sepassi, Stephen King, Simon Holland, Luigi Martini, M. Lawrence (2013)
Characterization of polymer adsorption onto drug nanoparticles using depletion measurements and small-angle neutron scattering.Molecular pharmaceutics, 10 11
Andreas Niederquell, A. Völker, M. Kuentz (2012)
Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules.International journal of pharmaceutics, 426 1-2
B. Eerdenbrugh, G. Mooter, P. Augustijns (2008)
Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products.International journal of pharmaceutics, 364 1
D. Koppel (1972)
Analysis of Macromolecular Polydispersity in Intensity Correlation Spectroscopy: The Method of CumulantsJournal of Chemical Physics, 57
Nicole Wyttenbach, W. Kirchmeyer, J. Alsenz, M. Kuentz (2016)
Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts.Molecular pharmaceutics, 13 1
Peng Ke, S. Hasegawa, Hisham Al-Obaidi, G. Buckton (2012)
Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions.International journal of pharmaceutics, 422 1-2
M. Vogt, Klaus Kunath, J. Dressman (2008)
Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 68 2
Renata Negrini, S. Aleandri, M. Kuentz (2017)
Study of Rheology and Polymer Adsorption Onto Drug Nanoparticles in Pharmaceutical Suspensions Produced by Nanomilling.Journal of pharmaceutical sciences, 106 11
Baoyan Zuo, Yinghua Sun, Hui Li, Xiaohong Liu, Yinglei Zhai, Jin Sun, Zhonggui He (2013)
Preparation and in vitro/in vivo evaluation of fenofibrate nanocrystals.International journal of pharmaceutics, 455 1-2
Zhi Loh, A. Samanta, P. Heng (2015)
Overview of milling techniques for improving the solubility of poorly water-soluble drugsAsian Journal of Pharmaceutical Sciences, 10
Maria Lestari, R. Müller, J. Möschwitzer (2015)
Systematic screening of different surface modifiers for the production of physically stable nanosuspensions.Journal of pharmaceutical sciences, 104 3
Gurpreet Suri, A. Kaur, T. Sen (2016)
A recent trend of drug-nanoparticles in suspension for the application in drug delivery.Nanomedicine, 11 21
O. Planinšek, J. Zadnik, M. Kunaver, S. Srčič, A. Godec (2010)
Structural evolution of indomethacin particles upon milling: time-resolved quantification and localization of disordered structure studied by IGC and DSC.Journal of pharmaceutical sciences, 99 4
Pharm Res (2018) 35:69 https://doi.org/10.1007/s11095-017-2300-6 RESEARCH PAPER 1 2 1 1 Simone Aleandri & Monica Schönenberger & Andres Niederquell & Martin Kuentz Received: 30 August 2017 /Accepted: 2 November 2017 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT is of importance for pharmaceutical development to achieve Purpose The trial-and-error approach is still predominantly desirable quality attributes of nanosuspensions. used in pharmaceutical development of nanosuspensions. . . Physicochemical dispersion stability is a primary focus and KEY WORDS atomic force microscopy nanosuspension . . therefore, various analytical bulk methods are commonly surface characterization surface dissolution wet-milling employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug ABBREVIATIONS nanosuspensions were to be studied for temperatures of 25 AFM Atomic force microscopy and 37°C by using complementary surface analytical BF Bezafibrate methods. BFns Bezafibrate nanosuspension Methods Atomic force microscopy, inverse gas chromatogra- DLS Dynamic light scattering phy and UV surface dissolution imaging were used together DSC Differential scanning calorimetry for the first time to assess pharmaceutical nanosuspensions DWS Diffusing wave spectroscopy that were obtained by wet milling. Fenofibrate and FF Fenofibrate bezafibrate were selected
Pharmaceutical Research – Springer Journals
Published: Feb 21, 2018
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