Pharm Res (2018) 35:69 https://doi.org/10.1007/s11095-017-2300-6 RESEARCH PAPER 1 2 1 1 Simone Aleandri & Monica Schönenberger & Andres Niederquell & Martin Kuentz Received: 30 August 2017 /Accepted: 2 November 2017 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT is of importance for pharmaceutical development to achieve Purpose The trial-and-error approach is still predominantly desirable quality attributes of nanosuspensions. used in pharmaceutical development of nanosuspensions. . . Physicochemical dispersion stability is a primary focus and KEY WORDS atomic force microscopy nanosuspension . . therefore, various analytical bulk methods are commonly surface characterization surface dissolution wet-milling employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug ABBREVIATIONS nanosuspensions were to be studied for temperatures of 25 AFM Atomic force microscopy and 37°C by using complementary surface analytical BF Bezafibrate methods. BFns Bezafibrate nanosuspension Methods Atomic force microscopy, inverse gas chromatogra- DLS Dynamic light scattering phy and UV surface dissolution imaging were used together DSC Differential scanning calorimetry for the first time to assess pharmaceutical nanosuspensions DWS Diffusing wave spectroscopy that were obtained by wet milling. Fenofibrate and FF Fenofibrate bezafibrate were selected
Pharmaceutical Research – Springer Journals
Published: Feb 21, 2018
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