Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Boesgaard, J. Žilinskaitė, M. Vänttinen, M. Laakso, Per-Anders Jansson, A. Hammarstedt, Ulf Smith, Norbert Stefan, Andreas Fritsche, HU Häring, M. Hribal, Giorgio Sesti, Dorit Zobel, O. Pedersen, Oluf Pedersen, T. Hansen (2008)
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 studyDiabetologia, 51
R. Watanabe, H. Allayee, A. Xiang, E. Trigo, J. Hartiala, J. Lawrence, T. Buchanan (2007)
Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican AmericansDiabetes, 56
C. Marzi, C. Huth, M. Kolz, H. Grallert, C. Meisinger, H. Wichmann, W. Rathmann, C. Herder, T. Illig (2007)
Variants of the Transcription Factor 7-Like 2 Gene (TCF7L2) are Strongly Associated with Type 2 Diabetes but not with the Metabolic Syndrome in the MONICA/KORA SurveysHormone and Metabolic Research, 39
M. Ng, C. Tam, V. Lam, W. So, R. Ma, J. Chan (2007)
Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.The Journal of clinical endocrinology and metabolism, 92 9
L. Scott, L. Bonnycastle, C. Willer, Andrew Sprau, A. Jackson, Narisu Narisu, W. Duren, P. Chines, H. Stringham, M. Erdos, T. Valle, J. Tuomilehto, R. Bergman, K. Mohlke, F. Collins, M. Boehnke (2006)
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish SampleDiabetes, 55
M. Horikoshi, K. Hara, C. Ito, R. Nagai, P. Froguel, T. Kadowaki (2007)
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese populationDiabetologia, 50
J. Xiang, Xiao-ying Li, Min Xu, Jie Hong, Yun Huang, Jiao‐Rong Tan, Xi Lu, M. Dai, Bing Yu, G. Ning (2008)
Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese.The Journal of clinical endocrinology and metabolism, 93 10
Andreas Dahlgren, B. Zethelius, Karin Jensevik, A. Syvänen, Christian Berne (2007)
Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly menDiabetologia, 50
R. Loos, P. Franks, R. Francis, I. Barroso, F. Gribble, D. Savage, K. Ong, S. O’Rahilly, N. Wareham (2007)
TCF7L2 Polymorphisms Modulate Proinsulin Levels and β-Cell Function in a British Europid PopulationDiabetes, 56
D. Bodhini, V. Radha, M. Dhar, N. Narayani, V. Mohan (2007)
The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.Metabolism: clinical and experimental, 56 9
D. Matthews, J. Hosker, A. Rudenski, B. Naylor, D. Treacher, R. Turner (1985)
Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 28
L.J. Scott, K.L. Mohlke, L.L. Bonnycastle (2007)
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility VariantsScience, 316
Cuilin Zhang, L. Qi, D. Hunter, J. Meigs, J. Manson, R. Dam, F. Hu (2006)
Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and MenDiabetes, 55
M.C. Ng, K.S. Park, B. Oh (2008)
Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6.719 AsiansDiabetes, 57
R. Saxena, Lauren Gianniny, N. Burtt, V. Lyssenko, Candace Giuducci, M. Sjögren, J. Florez, P. Almgren, B. Isomaa, M. Orho-Melander, U. Lindblad, M. Daly, T. Tuomi, J. Hirschhorn, K. Ardlie, L. Groop, D. Altshuler (2006)
Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic IndividualsDiabetes, 55
G. Xavier, M. Loder, A. McDonald, A. Tarasov, R. Carzaniga, K. Kronenberger, S. Barg, G. Rutter (2009)
TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-CellsDiabetes, 58
B. Balkau, M.A. Charles (1999)
Comment on the Provisional Report from the WHO Consultation: European Group for the Study of Insulin Resistance (EGIR)Diabet. Med., 16
J. Florez, K. Jablonski, N. Bayley, T. Pollin, P. Bakker, A. Shuldiner, W. Knowler, D. Nathan, D. Altshuler (2006)
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.The New England journal of medicine, 355 3
Nicholette Palmer, A. Lehtinen, C. Langefeld, Joel Campbell, S. Haffner, J. Norris, R. Bergman, M. Goodarzi, J. Rotter, D. Bowden (2008)
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.The Journal of clinical endocrinology and metabolism, 93 1
K. Alberti, P. Zimmet (1998)
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 15
R. Saxena, B. Voight, V. Lyssenko, N. Burtt, P. Bakker, Hong Chen, J. Roix, S. Kathiresan, J. Hirschhorn, M. Daly, T. Hughes, L. Groop, D. Altshuler, P. Almgren, J. Florez, Joanne Meyer, K. Ardlie, K. Boström, B. Isomaa, G. Lettre, U. Lindblad, H. Lyon, O. Melander, C. Newton‐Cheh, P. Nilsson, M. Orho-Melander, L. Råstam, Elizabeth Speliotes, M. Taskinen, T. Tuomi, C. Guiducci, A. Berglund, J. Carlson, Lauren Gianniny, Rachel Hackett, Liselotte Hall, J. Holmkvist, E. Laurila, M. Sjögren, M. Sterner, Aarti Surti, M. Svensson, M. Svensson, R. Tewhey, B. Blumenstiel, Melissa Parkin, M. Defelice, Rachel Barry, W. Brodeur, J. Camarata, Na-Yu Chia, M. Fava, J. Gibbons, B. Handsaker, C. Healy, K. Nguyen, C. Gates, C. Sougnez, D. Gage, Marcia Nizzari, S. Gabriel, G. Chirn, Qicheng Ma, H. Parikh, D. Richardson, D. Ricke, S. Purcell (2007)
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride LevelsScience, 316
S. Humphries, D. Gable, J. Cooper, H. Ireland, J. Stephens, S. Hurel, Kawah Li, J. Palmen, Michelle Miller, F. Cappuccio, R. Elkeles, I. Godsland, G. Miller, P. Talmud (2006)
Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and womenJournal of Molecular Medicine, 84
Y. Horikawa, K. Miyake, K. Yasuda, M. Enya, Y. Hirota, K. Yamagata, Y. Hinokio, Y. Oka, N. Iwasaki, Y. Iwamoto, Yuichiro Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, Ken Yamamoto, K. Tokunaga, J. Takeda, M. Kasuga (2008)
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.The Journal of clinical endocrinology and metabolism, 93 8
J. Florez, J. Florez (2008)
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?Diabetologia, 51
Julian Muñoz, K. Lok, B. Gower, José Fernández, G. Hunter, C. Lara‐Castro, M. Luca, W. Garvey (2006)
Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic WomenDiabetes, 55
K. Kirchhoff, F. Machicao, A. Haupt, S. Schäfer, O. Tschritter, H. Staiger, N. Stefan, H. Häring, A. Fritsche (2008)
Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversionDiabetologia, 51
C. Groves, E. Zeggini, J. Minton, T. Frayling, M. Weedon, N. Rayner, G. Hitman, M. Walker, S. Wiltshire, A. Hattersley, M. McCarthy (2006)
Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual RiskDiabetes, 55
F. Luft (2005)
A fat attack occurred in fat cityJournal of Molecular Medicine, 84
E. Zeggini, M. Weedon, C. Lindgren, T. Frayling, K. Elliott, H. Lango, N. Timpson, J. Perry, N. Rayner, R. Freathy, J. Barrett, B. Shields, A. Morris, S. Ellard, C. Groves, L. Harries, J. Marchini, K. Owen, B. Knight, L. Cardon, M. Walker, G. Hitman, A. Morris, A. Doney, M. McCarthy, A. Hattersley (2007)
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 DiabetesScience, 316
S. Thomas, L. Scott, K. Mohlke, L. Bonnycastle, C. Willer, Yun Li, W. Duren, M. Erdos, H. Stringham, P. Chines, A. Jackson, T. Hu, R. Pruim, Rui Xiao, Xiao-yi Li, K. Conneely, Nancy Riebow, Andrew Sprau, Maurine Tong, P. White, K. Hetrick, M. Barnhart, T. Buchanan, R. Watanabe, T. Valle, G. Abecasis, E. Pugh, S. Collins, M. Boehnke
Supporting Online Material Materials and Methods Figs. S1 to S8 Tables S1 to S10 References a Genome-wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
L. Shu, N. Sauter, F. Schulthess, A. Matveyenko, J. Oberholzer, K. Maedler (2008)
Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic IsletsDiabetes, 57
S. Schäfer, O. Tschritter, F. Machicao, C. Thamer, Norbert Stefan, Baptist Gallwitz, J. Holst, J. Dekker, L. t’Hart, G. Nijpels, T. Haeften, HU Häring, Andreas Fritsche (2007)
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphismsDiabetologia, 50
V. Lyssenko, R. Lupi, P. Marchetti, S. Guerra, M. Orho-Melander, P. Almgren, M. Sjögren, C. Ling, K. Eriksson, ÅsaLinda Lethagen, R. Mancarella, G. Berglund, T. Tuomi, P. Nilsson, S. Prato, L. Groop (2007)
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.The Journal of clinical investigation, 117 8
R. Sladek, G. Rocheleau, J. Rung, C. Dina, Lishuang Shen, D. Serre, P. Boutin, Daniel Vincent, Alexandre Bélisle, S. Hadjadj, B. Balkau, B. Heude, G. Charpentier, T. Hudson, A. Montpetit, A. Pshezhetsky, M. Prentki, Barry Posner, D. Balding, D. Meyre, C. Polychronakos, P. Froguel (2007)
A genome-wide association study identifies novel risk loci for type 2 diabetesNature, 445
K.G.M.M. Alberti, P.Z. Zimmet (1998)
Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: 1. Diagnosis and Classification of Diabetes MellitusDiabet. Med., 15
F. Chimienti, A. Favier, M. Sève (2005)
ZnT-8, A Pancreatic Beta-Cell-Specific Zinc TransporterBiometals, 18
W. Friedewald, R. Levy, D. Fredrickson (1972)
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clinical chemistry, 18 6
Agnar Helgason, S. Pálsson, G. Thorleifsson, S. Grant, V. Emilsson, Steinunn Gunnarsdottir, A. Adeyemo, Yuanxiu Chen, Guanjie Chen, I. Reynisdottir, R. Benediktsson, A. Hinney, T. Hansen, G. Andersen, K. Borch-Johnsen, T. Jørgensen, H. Schäfer, M. Faruque, A. Doumatey, Jie Zhou, R. Wilensky, M. Reilly, D. Rader, Y. Bagger, C. Christiansen, G. Sigurdsson, J. Hebebrand, O. Pedersen, U. Thorsteinsdóttir, J. Gulcher, A. Kong, C. Rotimi, K. Stefánsson (2007)
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionNature Genetics, 39
A. Kamijo-Ikemori, Takeshi Sugaya, Takashi Yasuda, Takehiro Kawata, Akio Ota, Shinobu Tatsunami, Ruriko Kaise, Toshihiko Ishimitsu, Yasushi Tanaka, K. Kimura (2011)
Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic PatientsDiabetes Care, 34
G. Chandak, C. Janipalli, Seema Bhaskar, S. Kulkarni, P. Mohankrishna, A. Hattersley, T. Frayling, C. Yajnik (2006)
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian populationDiabetologia, 50
T. Jin, Ling Liu (2008)
The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.Molecular endocrinology, 22 11
J. Lewis, Nicholette Palmer, P. Hicks, M. Sale, C. Langefeld, B. Freedman, J. Divers, D. Bowden (2008)
Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association StudiesDiabetes, 57
S. Cauchi, H. Choquet, R. Gutiérrez-Aguilar, F. Capel, K. Grau, Christine Proença, C. Dina, A. Duval, B. Balkau, M. Marre, N. Potoczna, D. Langin, F. Horber, T. Sørensen, G. Charpentier, D. Meyre, P. Froguel (2008)
Effects of TCF7L2 Polymorphisms on Obesity in European PopulationsObesity, 16
B. Balkau, M. Charles (1999)
Comment on the provisional report from the WHO consultationDiabetic Medicine, 16
S. Cauchi, D. Meyre, C. Dina (2006)
Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human Beta-Cells and Adipose Tissue and Strong Association with Type 2 DiabetesDiabetes, 55
S. Cauchi, D. Meyre, C. Dina, H. Choquet, C. Samson, S. Gallina, B. Balkau, G. Charpentier, F. Pattou, V. Stetsyuk, R. Scharfmann, B. Staels, G. Frühbeck, P. Froguel (2006)
Transcription Factor TCF7L2 Genetic Study in the French PopulationDiabetes, 55
S. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, Agnar Helgason, H. Stefánsson, V. Emilsson, A. Helgadóttir, U. Styrkársdóttir, K. Magnússon, G. Walters, E. Pálsdóttir, T. Jonsdottir, T. Gudmundsdóttir, Arnaldur Gylfason, Jona Saemundsdottir, R. Wilensky, M. Reilly, D. Rader, Y. Bagger, C. Christiansen, V. Gudnason, Gunnar Sigurdsson, U. Thorsteinsdóttir, J. Gulcher, A. Kong, K. Stefánsson (2006)
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 38
E. Kawasaki, Mho Uga, Kazuhiko Nakamura, G. Kuriya, T. Satoh, Keiichiro Fujishima, M. Ozaki, N. Abiru, H. Yamasaki, J. Wenzlau, H. Davidson, J. Hutton, K. Eguchi (2008)
Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetesDiabetologia, 51
Genes TCF7L2 and SLC30A8, encoding transcription factor-4 and transmembrane zinc transporter-8, respectively, play an important role in the regulation of development, proliferation, and pancreatic β cell function. In the present study we examined polymorphic markers of genes rs12255372 [NT_03359.12:g33557428G->T] of TCF7L2 gene and rs13266634 [NP_776250.2:p.R325W] of SLC30A8 in groups of Russians with type 2 diabetes (T2D) (n = 588) and healthy normoglycemic controles (n = 597). Significant association of allele T (rs12255372) and allele R (rs13266634) with a higher risk of T2D development has been found (OR = 1.37 and 1.22, respectively). Adjustment for the effect of potential nongenetic risk factors resulted in a further increase in the OR values, from 1.54 (P = 0.24) to 1.89 (P = 0.046) for homozygous carriers of the T allele and from 1.29 (P = 0.035) to 1.35 (P = 0.019) in the individuals homozygous for the R allele. The patients homozygous for predisposing allele T (rs12255372) or R (rs13266634) had significantly lower insulin concentrations in the blood 2 h after glucose tolerance test (GTT) as well as lower values of HOMA-β, β cell homeostasis indicator compared to the carriers of other genotypes. Thus, we have shown that the rs12255372 and rs13266634 markers are independent genetic T2D risk factors in a Russian population.
Russian Journal of Genetics – Springer Journals
Published: Aug 17, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.