Mammalian Genome 9, 397-399 (1998). Mammalian Genome Incorporating Moose Gnome © Springer-Verlag New York Inc. 1998 TBX10, a member of the Tbxl-subfamily of conserved developmental genes, is located at human Chromosome 11q13 and proximal mouse Chromosome 19 David J. Law,' Nancy Garvey, 2 Sergei I. Agulnik, 2 Victor Perlroth, 2 O1wen M. Hahn, 2 Rita E. Rhinehart, l Thomas C. Gebuhr, l Lee M. Silver 2 `Human Genome Center and Department of Human Genetics, 1150 West Medical Center Drive, 3514 MSRB 1, University of Michigan, Ann Arbor, Michigan 48109-0650, USA 2Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA Received: 9 October 1997 / Accepted: 9 January 1998 The T-box developmental gene family was originally described in lated, but distinct, member of the Tbxl subfamily, which we have the mouse (Bollag et al. 1994), and homologs were subsequently designated TBX10. identified in a wide variety of metazoans (Agulnik et al. 1995). By FISH analysis, human TBX10 maps to Chr 11q13 (Fig. 1). T-box genes encode transcription factors that are expressed differ- To refine the map location, human TBX10 was isolated in a entially during embryogenesis and/or in tissue-specific fashion CEPH/Genethon YAC contig linked to anonymous markers span-
Mammalian Genome – Springer Journals
Published: Mar 27, 2009
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