Taxonomic reassessment of N4-like viruses using comparative genomics and proteomics suggests a new subfamily - “ Enquartavirinae ”

Taxonomic reassessment of N4-like viruses using comparative genomics and proteomics suggests a... The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “ G7cvirus ” (consisting of phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “ Lit1virus ” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “ Sp58virus ” (SP058 and SP076), and “ Dss3virus ” (DSS3φ2 and EE36φ1). We propose that coliphage N4, the members of “ G7cvirus ”, Erwinia phage Ea9-2, and Achromobacter phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “ Enquartavirinae ”. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Taxonomic reassessment of N4-like viruses using comparative genomics and proteomics suggests a new subfamily - “ Enquartavirinae ”

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2609-6
Publisher site
See Article on Publisher Site

Abstract

The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “ G7cvirus ” (consisting of phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “ Lit1virus ” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “ Sp58virus ” (SP058 and SP076), and “ Dss3virus ” (DSS3φ2 and EE36φ1). We propose that coliphage N4, the members of “ G7cvirus ”, Erwinia phage Ea9-2, and Achromobacter phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “ Enquartavirinae ”.

Journal

Archives of VirologySpringer Journals

Published: Dec 1, 2015

References

  • The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective
    Paddison, P; Abedon, ST; Dressman, HK; Gailbreath, K; Tracy, J

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