Targeted delivery and thermo/pH-controlled release of doxorubicin by novel nanocapsules

Targeted delivery and thermo/pH-controlled release of doxorubicin by novel nanocapsules The ideal drug delivery system (DDS) should be able to deliver a therapeutic dose of drug to the target site in the body and maintain appropriate concentration over a desired period of time. Thermo/pH-responsive targeted polymeric nanocapsules (p(NIPA-co-AAc-co-GAA)) for delivery of anticancer drug (doxorubicin, DOX) were fabricated by W/O/W double emulsion solvent evaporation technique. The morphology, hydrodynamic diameter, size distribution, thermo/pH responsiveness, targeted property, anti-tumor efficacy, encapsulation efficiency, drug loading and controlled release of drug were systematically investigated. The results demonstrated that p(NIPA-co-AAc-co-GAA) nanocapsules minimized the drug leakage and reduced the toxic and side effects on normal tissues, while triggered and accelerated the release of drug in tumor tissues. It is very interesting for the site-specific release of drug to improve curative effects and reduce side effects, implying that p(NIPA-co-AAc-co-GAA) nanocapsule is a attractive candidate for DDS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science Springer Journals

Targeted delivery and thermo/pH-controlled release of doxorubicin by novel nanocapsules

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Materials Science; Materials Science, general; Characterization and Evaluation of Materials; Polymer Sciences; Continuum Mechanics and Mechanics of Materials; Crystallography and Scattering Methods; Classical Mechanics
ISSN
0022-2461
eISSN
1573-4803
D.O.I.
10.1007/s10853-017-1679-0
Publisher site
See Article on Publisher Site

Abstract

The ideal drug delivery system (DDS) should be able to deliver a therapeutic dose of drug to the target site in the body and maintain appropriate concentration over a desired period of time. Thermo/pH-responsive targeted polymeric nanocapsules (p(NIPA-co-AAc-co-GAA)) for delivery of anticancer drug (doxorubicin, DOX) were fabricated by W/O/W double emulsion solvent evaporation technique. The morphology, hydrodynamic diameter, size distribution, thermo/pH responsiveness, targeted property, anti-tumor efficacy, encapsulation efficiency, drug loading and controlled release of drug were systematically investigated. The results demonstrated that p(NIPA-co-AAc-co-GAA) nanocapsules minimized the drug leakage and reduced the toxic and side effects on normal tissues, while triggered and accelerated the release of drug in tumor tissues. It is very interesting for the site-specific release of drug to improve curative effects and reduce side effects, implying that p(NIPA-co-AAc-co-GAA) nanocapsule is a attractive candidate for DDS.

Journal

Journal of Materials ScienceSpringer Journals

Published: Oct 16, 2017

References

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