Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy

Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy Strahlenther Onkol (2018) 194:255–263 https://doi.org/10.1007/s00066-017-1224-8 ORIGINAL ARTICLE Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy A comparison of benefits 1 2 1 1 3 Peter de Boer · Agustinus J. A. J. van de Schoot · Henrike Westerveld ·Mark Smit · Marrije R. Buist · 1 1 1 Arjan Bel · Coen R.N.Rasch ·Lukas J.A.Stalpers Received: 2 December 2016 / Accepted: 5 October 2017 / Published online: 3 November 2017 © The Author(s) 2017. This article is an open access publication. Abstract Results Both IMPT and MRI-based target tailoring resulted Purpose The aim of the study was to investigate the po- in significant reductions in V ,V ,V and D 15Gy 30Gy 45Gy mean tential clinical benefit from both target tailoring by exclud- for bladder and small bowel. IMPT reduced the NTCP for ing the tumour-free proximal part of the uterus during im- small bowel toxicity from 25% to 18%; this was further age-guided adaptive radiotherapy (IGART) and improved reduced to 9% when combined with MRI-based target tai- dose conformity based on intensity-modulated proton ther- loring. In four of the 11 patients (36%), NTCP reductions apy (IMPT). of >10% were estimated by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Strahlentherapie und Onkologie Springer Journals

Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Radiotherapy; Oncology
ISSN
0179-7158
eISSN
1439-099X
D.O.I.
10.1007/s00066-017-1224-8
Publisher site
See Article on Publisher Site

Abstract

Strahlenther Onkol (2018) 194:255–263 https://doi.org/10.1007/s00066-017-1224-8 ORIGINAL ARTICLE Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy A comparison of benefits 1 2 1 1 3 Peter de Boer · Agustinus J. A. J. van de Schoot · Henrike Westerveld ·Mark Smit · Marrije R. Buist · 1 1 1 Arjan Bel · Coen R.N.Rasch ·Lukas J.A.Stalpers Received: 2 December 2016 / Accepted: 5 October 2017 / Published online: 3 November 2017 © The Author(s) 2017. This article is an open access publication. Abstract Results Both IMPT and MRI-based target tailoring resulted Purpose The aim of the study was to investigate the po- in significant reductions in V ,V ,V and D 15Gy 30Gy 45Gy mean tential clinical benefit from both target tailoring by exclud- for bladder and small bowel. IMPT reduced the NTCP for ing the tumour-free proximal part of the uterus during im- small bowel toxicity from 25% to 18%; this was further age-guided adaptive radiotherapy (IGART) and improved reduced to 9% when combined with MRI-based target tai- dose conformity based on intensity-modulated proton ther- loring. In four of the 11 patients (36%), NTCP reductions apy (IMPT). of >10% were estimated by

Journal

Strahlentherapie und OnkologieSpringer Journals

Published: Nov 3, 2017

References

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