Strahlenther Onkol (2018) 194:255–263 https://doi.org/10.1007/s00066-017-1224-8 ORIGINAL ARTICLE Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy A comparison of beneﬁts 1 2 1 1 3 Peter de Boer · Agustinus J. A. J. van de Schoot · Henrike Westerveld ·Mark Smit · Marrije R. Buist · 1 1 1 Arjan Bel · Coen R.N.Rasch ·Lukas J.A.Stalpers Received: 2 December 2016 / Accepted: 5 October 2017 / Published online: 3 November 2017 © The Author(s) 2017. This article is an open access publication. Abstract Results Both IMPT and MRI-based target tailoring resulted Purpose The aim of the study was to investigate the po- in signiﬁcant reductions in V ,V ,V and D 15Gy 30Gy 45Gy mean tential clinical beneﬁt from both target tailoring by exclud- for bladder and small bowel. IMPT reduced the NTCP for ing the tumour-free proximal part of the uterus during im- small bowel toxicity from 25% to 18%; this was further age-guided adaptive radiotherapy (IGART) and improved reduced to 9% when combined with MRI-based target tai- dose conformity based on intensity-modulated proton ther- loring. In four of the 11 patients (36%), NTCP reductions apy (IMPT). of >10% were estimated by
Strahlentherapie und Onkologie – Springer Journals
Published: Nov 3, 2017
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