Reactions 1704, p354 - 2 Jun 2018 Symmetric drug-related intertriginous and flexural exanthema: case report A 41-year-old man developed symmetric drug-related intertriginous and flexural exanthema (SDRIFE) during treatment with tacrolimus as an immunosuppressant therapy [route and duration of treatment to reaction onset not stated]. The man had undergone a kidney and liver transplantation three years ago. Following the transplant, he started receiving tacrolimus 7mg daily. Nine months before presentation, he had developed a chronic, erythematous, itchy, papular eruption, which symmetrically affected his legs and arms including the groins, axillae, flexural folds, neck and gluteal region. He did not show any other signs or symptoms. A skin biopsy revealed epidermal spongiosis and a perivascular superficial and dermo-epidermal infiltrate, which were composed of histiocytes, lymphocytes and some eosinophils without the involvement of basal layer. Drug eruption and allergic contact dermatitis were suspected and patch tests were planned. The patch testing included tacrolimus ointment [Tarfic] at two different concentrations of 0.1% and 0.03% respectively, with occlusion of two days. On day four, his test was positive for cobalt, nickel and the tacrolimus ointment 0.1%. A diagnosis of the SDRIFE was made. The man started receiving corrective treatment with propranolol. His serum tacrolimus level was within normal range. Due to unavailability of everolimus, tacrolimus withdrawal was not possible. Hence, therapy with prednisone and clobetasol was started. Subsequently, most of his lesions cleared. The remaining lesions were treated with betamethasone valerate. Author comment: "Taken together, the clinical, exposure and histopathological features and the patch test results are consistent with a diagnosis of SDRIFE caused by tacrolimus". Scherrer M, et al. Tacrolimus-induced symmetric drug-related intertriginous and flexural exanthema (SDRIFE). Contact Dermatitis 78: 414-416, No. 6, Jun 2018. Available from: URL: http://doi.org/10.1111/cod.12954 - Brazil 803323310 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera