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Tacrolimus

Tacrolimus Reactions 1704, p353 - 2 Jun 2018 Renal toxicity: case report An 8-month-old male infant developed renal toxicity during treatment with tacrolimus [route, dosage, indication and duration of treatment to reaction onset not stated]. The infant, who had a progressive cholestatic liver cirrhosis, was scheduled for liver transplantation. He receiving treatment with tacrolimus at that time. During the operation, he required continuous veno-venous haemofiltration (CVVH) for volume management. He developed renal toxicity secondary to tacrolimus, due to which CVVH was continued even after the transplantation. The trough level of tacrolimus trasiently increased to 22 ng/mL. Subsequently, his renal function recovered and CVVH was stopped. Author comment: "Postoperatively, the patient continued to be dependent on [continuous venovenous hemofiltration], mainly due to tacrolimus renal toxicity (the trough of tacrolimus transiently rose to 22 ng/mL).""On top of his cardiac condition, his renal function was compromised due to both hepatorenal syndrome and tacrolimus toxicity." Yamada Y, et al. Successful management of living donor liver transplantation for biliary atresia with single ventricle physiology-from peri-transplant through total cavopulmonary connection: A case report. Pediatric Transplantation 22: e13118, No. 3, May 2018. Available from: URL: http://doi.org/10.1111/petr.13118 - Japan 803323230 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Tacrolimus

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018

Tacrolimus

Abstract

Reactions 1704, p353 - 2 Jun 2018 Renal toxicity: case report An 8-month-old male infant developed renal toxicity during treatment with tacrolimus [route, dosage, indication and duration of treatment to reaction onset not stated]. The infant, who had a progressive cholestatic liver cirrhosis, was scheduled for liver transplantation. He receiving treatment with tacrolimus at that time. During the operation, he required continuous veno-venous haemofiltration (CVVH) for volume management. He...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46996-x
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p353 - 2 Jun 2018 Renal toxicity: case report An 8-month-old male infant developed renal toxicity during treatment with tacrolimus [route, dosage, indication and duration of treatment to reaction onset not stated]. The infant, who had a progressive cholestatic liver cirrhosis, was scheduled for liver transplantation. He receiving treatment with tacrolimus at that time. During the operation, he required continuous veno-venous haemofiltration (CVVH) for volume management. He developed renal toxicity secondary to tacrolimus, due to which CVVH was continued even after the transplantation. The trough level of tacrolimus trasiently increased to 22 ng/mL. Subsequently, his renal function recovered and CVVH was stopped. Author comment: "Postoperatively, the patient continued to be dependent on [continuous venovenous hemofiltration], mainly due to tacrolimus renal toxicity (the trough of tacrolimus transiently rose to 22 ng/mL).""On top of his cardiac condition, his renal function was compromised due to both hepatorenal syndrome and tacrolimus toxicity." Yamada Y, et al. Successful management of living donor liver transplantation for biliary atresia with single ventricle physiology-from peri-transplant through total cavopulmonary connection: A case report. Pediatric Transplantation 22: e13118, No. 3, May 2018. Available from: URL: http://doi.org/10.1111/petr.13118 - Japan 803323230 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG.

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References