Tacrolimus

Tacrolimus Reactions 1704, p351 - 2 Jun 2018 Decreased glomerular filtration rate: 3 case reports A retrospective observational study described three patients (two men and one woman) aged 27 29 years, who experienced a decrease in glomerular filtration rate during treatment with tacrolimus for IgA nephropathy [time to reactions onsets and outcomes not stated]. The patients were commenced on tacrolimus 1 mg/day [routes not stated] in 2 divided doses at intervals of 12 hours after the cessation of other immunosuppressants. The patients developed a loss of eGFR > 15mL/min 1.73m from baseline. Their baseline eGFR values were 61.0, 54.2 and 107.7 mL/min 1.73m , respectively. Author comment: "[T]acrolimus, a potent calcineurin inhibitor, is effective in patients with refractory IgAN. However, its effective dose has not been defined, and some side effects were previously reported, including nephrotoxicity, severe infection, gastrointestinal symptoms, and metabolic complications." Hu T, et al. Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy. Medicine 97: e0610, No. 18, May 2018. Available from: URL: http:// doi.org/10.1097/MD.0000000000010610 - China 803323981 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Tacrolimus

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46994-x
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p351 - 2 Jun 2018 Decreased glomerular filtration rate: 3 case reports A retrospective observational study described three patients (two men and one woman) aged 27 29 years, who experienced a decrease in glomerular filtration rate during treatment with tacrolimus for IgA nephropathy [time to reactions onsets and outcomes not stated]. The patients were commenced on tacrolimus 1 mg/day [routes not stated] in 2 divided doses at intervals of 12 hours after the cessation of other immunosuppressants. The patients developed a loss of eGFR > 15mL/min 1.73m from baseline. Their baseline eGFR values were 61.0, 54.2 and 107.7 mL/min 1.73m , respectively. Author comment: "[T]acrolimus, a potent calcineurin inhibitor, is effective in patients with refractory IgAN. However, its effective dose has not been defined, and some side effects were previously reported, including nephrotoxicity, severe infection, gastrointestinal symptoms, and metabolic complications." Hu T, et al. Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy. Medicine 97: e0610, No. 18, May 2018. Available from: URL: http:// doi.org/10.1097/MD.0000000000010610 - China 803323981 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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