Reactions 1704, p351 - 2 Jun 2018
Decreased glomerular filtration rate: 3 case reports
A retrospective observational study described three patients
(two men and one woman) aged 27
29 years, who
experienced a decrease in glomerular filtration rate during
treatment with tacrolimus for IgA nephropathy [time to
reactions onsets and outcomes not stated].
The patients were commenced on tacrolimus 1 mg/day
[routes not stated] in 2 divided doses at intervals of 12 hours
after the cessation of other immunosuppressants. The patients
developed a loss of eGFR > 15mL/min 1.73m
Their baseline eGFR values were 61.0, 54.2 and
107.7 mL/min 1.73m
Author comment: "[T]acrolimus, a potent calcineurin
inhibitor, is effective in patients with refractory IgAN.
However, its effective dose has not been defined, and some
side effects were previously reported, including
nephrotoxicity, severe infection, gastrointestinal symptoms,
and metabolic complications."
Hu T, et al. Tacrolimus decreases proteinuria in patients with refractory IgA
nephropathy. Medicine 97: e0610, No. 18, May 2018. Available from: URL: http://
doi.org/10.1097/MD.0000000000010610 - China
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved