Reactions 1704, p351 - 2 Jun 2018 Decreased glomerular filtration rate: 3 case reports A retrospective observational study described three patients (two men and one woman) aged 27 29 years, who experienced a decrease in glomerular filtration rate during treatment with tacrolimus for IgA nephropathy [time to reactions onsets and outcomes not stated]. The patients were commenced on tacrolimus 1 mg/day [routes not stated] in 2 divided doses at intervals of 12 hours after the cessation of other immunosuppressants. The patients developed a loss of eGFR > 15mL/min 1.73m from baseline. Their baseline eGFR values were 61.0, 54.2 and 107.7 mL/min 1.73m , respectively. Author comment: "[T]acrolimus, a potent calcineurin inhibitor, is effective in patients with refractory IgAN. However, its effective dose has not been defined, and some side effects were previously reported, including nephrotoxicity, severe infection, gastrointestinal symptoms, and metabolic complications." Hu T, et al. Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy. Medicine 97: e0610, No. 18, May 2018. Available from: URL: http:// doi.org/10.1097/MD.0000000000010610 - China 803323981 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera