Russian Journal of Developmental Biology, Vol. 32, No. 3, 2001, pp. 157–163. Translated from Ontogenez, Vol. 32, No. 3, 2001, pp. 196–203. Original Russian Text Copyright © 2001 by Korzh. REVIEWS V. P. Korzh Institute of Molecular Agrobiology, 1 Research Link, The National University of Singapore, 117604 Singapore e-mail: firstname.lastname@example.org Received December 07, 1999 INTRODUCTION formation of cartilage and, subsequently, the vertebral DEVELOPMENT OF BODY AXIS column is also dependent on Hedgehog signaling of the notochord (Evelyn Chiang, personal communication). During gastrulation in vertebrate embryos, three In general, the notochord signaling mediated by deﬁnitive germ layers (ectoderm, mesoderm, and endo- Hedgehog proteins contributes to the development of derm) are formed by organized and coordinated cell several specialized types of cells surrounding the noto- movements. In zebraﬁsh, further subdivision of the chord from all sides: dorsally, ventrally, and laterally. mesoderm gives rise to the axial, adaxial and paraxial This illustrates the role of the notochord as an impor- mesoderm. The axial mesoderm contributes to the pre- tant organizing center of the body axis in the vertebrate chordal plate and notochord, whereas the adaxial and embryo. Further, it emphasizes the importance of gene paraxial cells give rise to slow and fast
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 9, 2004
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