Background Dehydroepiandrosterone (DHEA) is helpful for evaluable blood and 46 contributed evaluable cytology and treating vaginal symptoms. This secondary analysis evaluated pH values. Circulating DHEA-S and testosterone levels were the impact of vaginal DHEA on hormone concentrations, significantly increased in those on vaginal DHEA in a dose- bone turnover, and vaginal cytology in women with a cancer dependent manner compared to PM. Estradiol was significant- history. ly increased in those on 6.5 mg/day DHEA but not in those on Methods Postmenopausal women, diagnosed with breast or 3.25 mg/day DHEA (p <0.05 and p = 0.05, respectively), and gynecologic cancer, were eligible if they reported at least not in those on AIs. Biomarkers of bone formation were un- moderate vaginal symptoms. Participants could be on tamox- changed in all arms. Maturation of vaginal cells was 100% ifen or aromatase inhibitors (AIs). Women were randomized (3.25 mg/day), 86% (6.5 mg/day), and 64% (PM); pH de- to 3.25 versus 6.5 mg/day of DHEA versus a plain moisturizer creased more in DHEA arms. (PM) control. Sex steroid hormone levels, biomarkers of bone Conclusion DHEA resulted in increased hormone concentra- formation, vaginal pH, and maturation index were collected at tions, though still in the
Supportive Care in Cancer – Springer Journals
Published: Nov 21, 2017
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