Systematic review of liposomes’ characterization methods

Systematic review of liposomes’ characterization methods Monatsh Chem (2017) 148:1581–1593 DOI 10.1007/s00706-017-1994-9 REVIEW 1,2 1 Ma ´ ria Kana ´ sova ´ Karel Nesme ˇra ´ k Received: 24 January 2017 / Accepted: 9 May 2017 / Published online: 10 July 2017 Springer-Verlag Wien 2017 Abstract An overview is provided for the instrumental composed of internal aqueous compartment surrounded by methods of characterizing liposomes, structures used as lipid bilayers, the membranes of which are formed by drug carriers. Included are the individual methods for the natural or synthetic lipids [1]. Liposomes can be either determination of their size, surface charge, encapsulation unilamellar or multilamellar, with sizes ranging from efficiency, the quantification of their individual compo- nanometers to micrometers in diameter [2, 3]. The forma- nents, and the determination of lamellarity. The tion of liposomes is a spontaneous process which occurs advantages and disadvantages of these methods are when phospholipids or other amphiphilic molecules with presented. specific properties are hydrated [4, 5]. The phospholipids Graphical abstract form shells because of hydrophobic effect of acyl chains in aqueous medium [6, 7]. This state is thermodynamically favorable and can be enhanced by hydrogen bonds, van der Waals forces, or other electrostatic interactions. Liposomes are currently very popular nanocarriers, Monatshefte für Chemie - Chemical Monthly Springer Journals

Systematic review of liposomes’ characterization methods

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Springer Vienna
Copyright © 2017 by Springer-Verlag Wien
Chemistry; Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry; Analytical Chemistry; Physical Chemistry; Theoretical and Computational Chemistry
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