J Membrane Biol (2014) 247:651–665 DOI 10.1007/s00232-014-9683-7 O R I G IN AL ARTI CL ES Synthetic Anionophores for Basic Anions as ‘‘Presumably, 2 2 OH /Cl Antiporters’’: From the Synthetic Ion Channels to Multi-ion Hopping, Anti-Hofmeister Selectivity, and Strong Positive AMFE Sofya Kostina Berezin Received: 18 December 2013 / Accepted: 13 May 2014 / Published online: 11 June 2014 Springer Science+Business Media New York 2014 Abstract We describe application of theory and kinetic implications of ﬁndings to the particular ﬁeld and beyond modeling to study transport of basic anions by the small are discussed. synthetic molecules. The ﬁndings should equip researchers in the particular ﬁeld with a tool necessary to address an Keywords Proton and hydroxide permeability Anion essential question: whether a given anion transporter exchange Anionophore Anomalous Mole-Fraction - - - - facilitates permeation of F ,CH COO ,N , and SCN Effect (AMFE) Synthetic ion channels Basic anions 3 3 across biological membrane or it does not. The basic anions undergo hydrolysis and conjugate acids (HAnion) are permeant species. However, because methods to Introduction quantitatively account for HAnion transport do not exist, traditionally, the phenomenon is also treated as non-exist- Number
The Journal of Membrane Biology – Springer Journals
Published: Jun 11, 2014
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